antibody

HP1-gamma Polyclonal Antibody

A-4017-100

100 µl

501.00 USD

polyclonal

domestic rabbit

nonconjugated

polyclonal

human, mouse, rat

western blot, immunohistochemistry, immunocytochemistry

A-4017-100

501.00 USD

HP1-gamma Polyclonal Antibody

100 µl

Rabbit

HP1-GAMMA

Unconjugated

Polyclonal

Human, Mouse, Rat

WB, IHC, IF; Recommended dilution: WB: 1:500-1:2000, IHC: 1:50-1:200, IF:1:50-1:200

IgG

Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human CBX3 (NP_009207.2).

Shipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles

Q13185

CBX3

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Affinity Purification

CBX 3 antibody, Chromobox homolog 3 (HP1 gamma homolog, Drosophila) antibody, Chromobox protein homolog 3 antibody, GAMMA antibody, HECH antibody, Heterochromatin protein 1 homolog gamma antibody, Heterochromatin protein HP1 gamma antibody, HP1 gamma antibody, HP1Hs gamma antibody, Modifier 2 protein antibody, HECH, HP1-GAMMA, HP1Hs-gamma

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.