PRMT5 Polyclonal Antibody | Epigentek A-3005-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

PRMT5 Polyclonal Antibody

catalog :

A-3005-100

quantity :

100 µl

price :

403.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Epigentek product webpage

citations: 2

Reference
Jia Z, Yue F, Chen X, Narayanan N, Qiu J, Syed S, et al. Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues. Adv Sci (Weinh). 2020;7:2002602 pubmed publisher
Scaglione A, Patzig J, Liang J, Frawley R, Bok J, Mela A, et al. PRMT5-mediated regulation of developmental myelination. Nat Commun. 2018;9:2840 pubmed publisher

product information

Catalog# :

A-3005

Part # :

A-3005-100

2022 Price (US) :

403.00 USD

Product Description (Product Name) :

PRMT5 Polyclonal Antibody

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

PRMT5

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Human, Mouse, Rat

Applications :

WB, IHC, IF; Recommended dilution: WB: 1:500-1:2000, IHC: 1:50-1:100, IF:1:50-1:200

Isotype :

IgG

Citations :

30026560, 31533041, 32555249

Immunogen :

A synthetic peptide corresponding to a sequence within amino acids 40-140 of human PRMT5 (NP_006100.2).

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles

Uniprot ID :

O14744

Gene :

PRMT5

Storage Buffer :

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purity :

Affinity Purification

Alternative Names :

72 kDa ICln binding protein antibody, ANM5_HUMAN antibody, Histone synthetic lethal 7 S. cerevisiae homolog of antibody, Histone-arginine N-methyltransferase PRMT5 antibody, HMT1 hnRNP methyltransferase like 5 antibody, HRMT1L5 antibody, IBP72 antibody, Jak-binding protein 1 antibody, JBP 1 antibody, PRMT 5 antibody, Protein arginine N methyltransferase 5 N terminally processed antibody, S. Pombe antibody, Shk1 kinase binding protein 1 homolog antibody, SKB 1 antibody, SKB1Hs antibody

Background :

Human Skb1Hs methyltransferase (also called JBP1), a homologue of yeast protein Skb1 and Hsl7p, is composed of 637 amino acid residues and contains motifs conserved among protein methyltransferases. It methylates histones and MBP in vitro. Yeast Hsl7p is involved in regulation of cell cycle progression through G2 by negatively regulating Swe1p, a protein tyrosine kinase that phosphorylates and inhibits Cdc28p. An Hsl7p homologue, Skb1, was identified in fission yeast by virtue of its yeast two-hybrid interaction with Shk1p, a p21 (cdc42p/Rac) activated kinase (PAK). Both proteins belong to the protein methyltransferase superfamily. Interestingly, human Skb1Hs methyltransferase was shown to interact with Jak kinases. This suggests the possibility that the Skb1Hs methyltransferase could link Jak to a PAK signaling pathway in mammalian cells.

more info or order :

Epigentek product webpage