antibody

SFN Polyclonal Antibody

A-2745-100

100 µl

308.00 USD

polyclonal

domestic rabbit

nonconjugated

polyclonal

human, mouse, rat

western blot, immunohistochemistry, immunocytochemistry

A-2745-100

308.00 USD

SFN Polyclonal Antibody

100 µl

Rabbit

SFN

Unconjugated

Polyclonal

Human, Mouse, Rat

WB, IHC, IF; Recommended dilution: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

IgG

Recombinant Protein of Human SFN

Shipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze.

P31947

SFN

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Affinity Purified

14-3-3 protein sigma

SFN, also known as 14-3-3 s, is a secreted adaptor protein that can regulate signaling pathways - both general and specific. 14-3-3 proteins regulate a number of cellular processes associated with cancer, particularly apoptosis, mitogenic signaling and cell-cycle checkpoints. This protein is expressed primarily in stratified squamous keratinising epithelium and is able to bind and modify the activity of many proteins by recognizing a phosphothreonine or phosphoserine motif. This protein can upregulate protein synthesis and cell growth, thereby stimulating the Akt/mTOR signaling pathway when it is bound to Keratin 17. In addition, SFN (or 14-3-3 s) can positively mediate IGF-I-induced cell cycle progression and bind to a various translation initiation factors, hence regulating mitotic translation. SFN positively regulates the tumor suppressor p53 and enhances the rate of p53-regulated inhibition of G2/M cell cycle progression. Alternative splicing allows several isoforms to exist for this protein.