CTCF Polyclonal Antibody | Epigentek A-2741-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

CTCF Polyclonal Antibody

catalog :

A-2741-100

quantity :

100 µl

price :

308.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

more info or order :

Epigentek product webpage

product information

Catalog# :

A-2741

Part # :

A-2741-100

2022 Price (US) :

308.00 USD

Product Description (Product Name) :

CTCF Polyclonal Antibody

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

CTCF

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Human, Mouse, Rat, Monkey

Applications :

WB, IHC, IF, IP, ChIP

Isotype :

IgG

Immunogen :

Recombinant Protein of Human CTCF

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze.

Uniprot ID :

P49711

Gene :

CTCF

Storage Buffer :

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purity :

Affinity Purified

Alternative Names :

Transcriptional repressor CTCF

Background :

Highly conserved transcription factors CTCF (CCCTC-binding factor) and its paralog (BORIS) regulate transcriptional activation and repression, insulator function, and imprinting control regions (ICRs). Both CTCF and BORIS contain 11 conserved zinc finger domains that work together to bind the same DNA elements, even though they have different amino and carboxy termini. CTCF is ubiquitously expressed and influences transcriptional regulation of cell-growth regulated genes. It is also necessary for the enhancer-blocking activity of all known insulator elements and ICRs. CTCF DNA-binding is sensitive to DNA methylation, a mark that determines parent-of-origin selection of the imprinted allele. CTCF functions depend on interactions with various proteins and posttranslational modifications, such as phosphorylation, SUMOylation and poly(ADP-ribosyl)ation. In particular, poly(ADP-ribosyl)ation has been found to regulate CTCF insulator and chromatin barrier functions and may also affects the transcription of rRNA. Mutations in this gene have been associated with aggressive breast cancers, prostate cancers, and Wilms' tumors.

more info or order :

Epigentek product webpage