HIF1AN Polyclonal Antibody | Epigentek A-2719-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

HIF1AN Polyclonal Antibody

catalog :

A-2719-100

quantity :

100 µl

price :

308.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

Epigentek product webpage

product information

Catalog# :

A-2719

Part # :

A-2719-100

2022 Price (US) :

308.00 USD

Product Description (Product Name) :

HIF1AN Polyclonal Antibody

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

HIF1AN

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Human, Mouse, Rat

Applications :

WB, IHC, IF, IP; Recommended dilution: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200

Isotype :

IgG

Immunogen :

Recombinant Protein of Human HIF1AN

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze.

Uniprot ID :

Q9NWT6

Gene :

HIF1AN

Storage Buffer :

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purity :

Affinity Purified

Alternative Names :

FIH1

Background :

Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

more info or order :

Epigentek product webpage