IDH1 Polyclonal Antibody | Epigentek A-2708-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

IDH1 Polyclonal Antibody

catalog :

A-2708-100

quantity :

100 µl

price :

308.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human, mouse

application :

western blot

more info or order :

Epigentek product webpage

product information

Catalog# :

A-2708

Part # :

A-2708-100

2022 Price (US) :

308.00 USD

Product Description (Product Name) :

IDH1 Polyclonal Antibody

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

IDH1

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Human, Mouse

Applications :

WB; Recommended dilution: WB 1:500 - 1:2000

Isotype :

IgG

Immunogen :

Recombinant Protein of Human IDH1

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze.

Uniprot ID :

O75874

Gene :

IDH1

Storage Buffer :

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purity :

Affinity Purified

Alternative Names :

IDCD, IDH, IDP, IDPC, PICD

Background :

IDH1 is one of three isocitrate dehydrogenases that catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG). These enzymes exist in two distinct subclasses that utilize either NAD or NADP+ respectively, as an electron acceptor. IDH1 is the NADP+-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. IDH2 and 3 are mitochondrial enzymes that also function in the Krebs cycle. IDH1 is inactivated by phosphorylation at Ser113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock. IDH1 is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

more info or order :

Epigentek product webpage