EGLN1 Polyclonal Antibody | Epigentek A-2702-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

EGLN1 Polyclonal Antibody

catalog :

A-2702-100

quantity :

100 µl

price :

308.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot

more info or order :

Epigentek product webpage

product information

Catalog# :

A-2702

Part # :

A-2702-100

2022 Price (US) :

308.00 USD

Product Description (Product Name) :

EGLN1 Polyclonal Antibody

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

EGLN1

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Human, Monkey

Applications :

WB; Recommended dilution: WB 1:500 - 1:2000

Isotype :

IgG

Immunogen :

Recombinant Protein of Human EGLN1

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze.

Uniprot ID :

Q9GZT9

Gene :

EGLN1

Storage Buffer :

PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purity :

Affinity Purified

Alternative Names :

EGLN1, C1orf12, DKFZp761F179, ECYT3, HIFPH2, HPH2, PHD2, SM-20, SM20, ZMYND6

Background :

PHD1 (Egln2), PHD-2 (Egln1), and PHD3 (Egln3) are members of the Egln family of proline hydroxylases. They function as oxygen sensors that catalyze the hydroxylation of HIF on prolines 564 and 402, initiating the first step of HIF degradation through the VHL/ubiquitin pathway. PHD1 is highly expressed in a wide array of tissues whereas PHD2 and PHD3 are expressed mainly in heart and skeletal muscle. The mRNA levels of PHD are upregulated by HIF through the hypoxia-response element under low oxygen conditions. These three enzymes also exhibit different peptide specificity target proteins, PHD1 and PHD2 can hydroxylate both proline 402 and proline 564, but PHD3 can only hydroxylate proline 564. In addition to HIF, PHD enzymes have also has been shown to catalyze the hydroxylation of RNA polymerase subunits and myogenin.

more info or order :

Epigentek product webpage