5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody [HMC/4D9] | Epigentek A-1018-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody [HMC/4D9]

catalog :

A-1018-100

quantity :

100 µg

price :

387.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HMC/4D9

application :

ELISA, immunohistochemistry, immunocytochemistry

more info or order :

Epigentek product webpage

citations: 3

Reference
Qu K, Ma X, Li G, Zhang H, Liu Y, Zhang K, et al. Vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells. Int J Biol Macromol. 2017;98:637-645 pubmed publisher
Wei H, Feng Y, Liang F, Cheng W, Wu X, Zhou R, et al. Role of oxidative stress and DNA hydroxymethylation in the neurotoxicity of fine particulate matter. Toxicology. 2017;380:94-103 pubmed publisher
Costa L, Da Silva I, Mariz B, da Silva M, Freitas Ribeiro G, De Oliveira N. Influence of smoking on methylation and hydroxymethylation levels in global DNA and specific sites of KRT14, KRT19, MIR-9-3 and MIR-137 genes of oral mucosa. Arch Oral Biol. 2016;72:56-65 pubmed publisher

product information

Catalog# :

A-1018

Part # :

A-1018-100

2022 Price (US) :

387.00 USD

Product Description (Product Name) :

5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody [HMC/4D9]

Size :

100 µg

Host :

Mouse

Antigen (Uniprot Accession, Gene or prot ... :

5-hmC

Conjugate :

Unconjugated

Clonality :

Monoclonal

Clone :

HMC/4D9

Species/Reactivity :

Broad Range

Applications :

IF, IHC, ELISA, DB, MeDIP

Isotype :

IgG1

Shipping Temp :

Shipped at 4°C. Aliquot store at -20°C . Avoid repeated freeze / thaw cycles.

Storage Buffer :

10 mM phosphate buffer, 150 mM NaCl, pH 7.4

Purity :

Affinity Purified

Alternative Names :

5-hydroxymethylcytidine, anti-5-hydroxymethylcytidine, anti-5-hydroxymethylcytosine, anti-5hmC, anti-5-hmC, anti-5-hmeC, anti-5hmeC, 5hmC, 5hmeC, 5-hmeC

Background :

5-hydroxymethylcytosine (5-hmC), as a sixth DNA base with functions in transcription regulation, has been detected to be abundant in human and mouse brain and embryonic stem (ES) cells. In mammals, it can be generated by oxidation of 5-methylcytosine (5-mC), a reaction mediated by the ten-eleven translocation (TET) family of 5-mC hydroxylases. 5-hmC was demonstrated to play an important and different role than 5-mC in the regulation of DNA methylation, chromatin remodeling, and gene expression

more info or order :

Epigentek product webpage