MGMT Polyclonal Antibody | Epigentek A-1010-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

MGMT Polyclonal Antibody

catalog :

A-1010-100

quantity :

100 µl

price :

403.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human, mouse

application :

western blot

more info or order :

Epigentek product webpage

citations: 1

Reference
Chen Y, Zhang Y, Dong T, Xu Y, Zhang W, An T, et al. Hyperthermia with different temperatures inhibits proliferation and promotes apoptosis through the EGFR/STAT3 pathway in C6 rat glioma cells. Mol Med Rep. 2017;16:9401-9408 pubmed publisher

product information

Catalog# :

A-1010

Part # :

A-1010-100

2022 Price (US) :

403.00 USD

Product Description (Product Name) :

MGMT Polyclonal Antibody

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

MGMT

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Human, Mouse

Applications :

WB; Recommended dilution: WB: 1:500 - 1:2000

Isotype :

IgG

Citations :

https://pubmed.ncbi.nlm.nih.gov/29039593, 29039593

Immunogen :

Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human MGMT (XP_005252739.1).

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles

Uniprot ID :

P16455

Gene :

MGMT

Storage Buffer :

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purity :

Affinity Purification

Alternative Names :

6 O methylguanine DNA methyltransferase antibody, Agat antibody, AGT antibody, AI267024 antibody, EC 2.1.1.63 antibody, Methylated DNA protein cysteine methyltransferase antibody, Methylguanine DNA methyltransferase antibody, MGC107020 antibody, MGMT antibody, O 6 methylguanine DNA alkyltransferase antibody, O 6 methylguanine DNA methyltransferase antibody

Background :

O6-methylguanine methyltransferase (MGMT) is a ubiquitous DNA repair protein that removes O6 -alkyl-guanine lesions, primarily O6 -methyl-guanine from damaged DNA. It is a major contributor to cellular protection from the mutagenic, carcinogenic, and cytotoxic effects of DNA alkylation. Also, MGMT is frequently silenced due to abnormal methylation during cancer development. Consequently, the loss of MGMT activity that made the cell more likely to become a cancer cell in the first place also makes tumor cells more sensitive to radiation therapy and certain alkylating drugs.

more info or order :

Epigentek product webpage