product summary
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company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Heme-oxygenase 1
catalog :
SPA-895
conjugate :
nonconjugated
reactivity :
guinea pig, human, mouse, rat
application :
western blot, immunohistochemistry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 41
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 2g
Choi E, Jeong J, Jang H, Ahn Y, Kim K, An H, et al. Skeletal Lipocalin-2 Is Associated with Iron-Related Oxidative Stress in ob/ob Mice with Sarcopenia. Antioxidants (Basel). 2021;10: pubmed publisher
  • immunohistochemistry; mouse; 1:250; loading ...; fig 3c
  • western blot; mouse; 1:1000; loading ...; fig 3b
Park G, Lee J, Han H, An H, Jin Z, Jeong E, et al. Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus. Cell Death Dis. 2021;12:445 pubmed publisher
  • immunohistochemistry; guinea pig; fig 2
Deuel J, Schaer C, Boretti F, Opitz L, Garcia Rubio I, Baek J, et al. Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response. Cell Death Dis. 2016;7:e2064 pubmed publisher
  • western blot; mouse; fig 4
Chiou S, Ha C, Wu P, Yeh C, Su Y, Li M, et al. Antioxidant, Anti-Tyrosinase and Anti-Inflammatory Activities of Oil Production Residues from Camellia tenuifloria. Int J Mol Sci. 2015;16:29522-41 pubmed publisher
  • western blot; human; 1:1000; fig 1B
Konzack A, Jakupovic M, Kubaichuk K, Görlach A, Dombrowski F, Miinalainen I, et al. Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. Antioxid Redox Signal. 2015;23:1059-75 pubmed publisher
  • immunohistochemistry; mouse; 1:5000; loading ...; tbl 2
Seemann S, Lupp A. Administration of a CXCL12 Analog in Endotoxemia Is Associated with Anti-Inflammatory, Anti-Oxidative and Cytoprotective Effects In Vivo. PLoS ONE. 2015;10:e0138389 pubmed publisher
  • western blot; rat; 1:1000; fig 5
Wu P, Yen J, Kou M, Wu M. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. PLoS ONE. 2015;10:e0130599 pubmed publisher
  • western blot; human; 1:1000; fig 5
Lundvig D, Pennings S, Brouwer K, Mtaya Mlangwa M, Mugonzibwa E, Kuijpers Jagtman A, et al. Cytoprotective responses in HaCaT keratinocytes exposed to high doses of curcumin. Exp Cell Res. 2015;336:298-307 pubmed publisher
  • western blot; mouse; 1:2000; fig 2
Xiao Y, Karnati S, Qian G, Nenicu A, Fan W, Tchatalbachev S, et al. Cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathways. PLoS ONE. 2012;7:e41097 pubmed publisher
  • chromatin immunoprecipitation; human
  • western blot; human
  • immunohistochemistry - paraffin section; mouse; fig 2
  • western blot; mouse; fig 2
Kim J, Zarjou A, Traylor A, Bolisetty S, Jaimes E, Hull T, et al. In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice. Kidney Int. 2012;82:278-91 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:2000
Hundahl C, Hannibal J, Fahrenkrug J, DeWilde S, Hay Schmidt A. Neuroglobin expression in the rat suprachiasmatic nucleus: colocalization, innervation, and response to light. J Comp Neurol. 2010;518:1556-69 pubmed publisher
Shin H, Jeong E, Lee J, An H, Jang H, Ahn Y, et al. Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death. Antioxidants (Basel). 2021;10: pubmed publisher
Ahn Y, Lim J, Kim H. Docosahexaenoic Acid Induces Expression of NAD(P)H: Quinone Oxidoreductase and Heme Oxygenase-1 through Activation of Nrf2 in Cerulein-Stimulated Pancreatic Acinar Cells. Antioxidants (Basel). 2020;9: pubmed publisher
Bugallo R, Marlin E, Baltanás A, Toledo E, Ferrero R, Vinueza Gavilanes R, et al. Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis. Cell Death Dis. 2020;11:397 pubmed publisher
Lee D, Yun S, Song M, Jung K, Kim E. Cyanidin Chloride Induces Apoptosis by Inhibiting NF-κB Signaling through Activation of Nrf2 in Colorectal Cancer Cells. Antioxidants (Basel). 2020;9: pubmed publisher
Chen Z, Zhong H, Wei J, Lin S, Zong Z, Gong F, et al. Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis. Arthritis Res Ther. 2019;21:300 pubmed publisher
Chinta K, Rahman M, Saini V, Glasgow J, Reddy V, Lever J, et al. Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis. Cell Rep. 2018;25:1938-1952.e5 pubmed publisher
Lazaro I, Lopez Sanz L, Bernal S, Oguiza A, Recio C, Melgar A, et al. Nrf2 Activation Provides Atheroprotection in Diabetic Mice Through Concerted Upregulation of Antioxidant, Anti-inflammatory, and Autophagy Mechanisms. Front Pharmacol. 2018;9:819 pubmed publisher
Reddy V, Chinta K, Saini V, Glasgow J, Hull T, Traylor A, et al. Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection. Front Immunol. 2018;9:860 pubmed publisher
Vaamonde García C, Courties A, Pigenet A, Laiguillon M, Sautet A, Houard X, et al. The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes-associated osteoarthritis. J Biol Chem. 2017;292:14505-14515 pubmed publisher
Ghosh A, Abdo S, Zhao S, Wu C, Shi Y, Lo C, et al. Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice. Endocrinology. 2017;158:903-919 pubmed publisher
Chavan H, Christudoss P, Mickey K, Tessman R, Ni H, Swerdlow R, et al. Arsenite Effects on Mitochondrial Bioenergetics in Human and Mouse Primary Hepatocytes Follow a Nonlinear Dose Response. Oxid Med Cell Longev. 2017;2017:9251303 pubmed publisher
Lin Y, Jean Y, Lee H, Lin S, Pan C, Chen W, et al. Excavatolide B Attenuates Rheumatoid Arthritis through the Inhibition of Osteoclastogenesis. Mar Drugs. 2017;15: pubmed publisher
Suttorp C, Xie R, Lundvig D, Kuijpers Jagtman A, Uijttenboogaart J, van Rheden R, et al. Orthodontic Forces Induce the Cytoprotective Enzyme Heme Oxygenase-1 in Rats. Front Physiol. 2016;7:283 pubmed publisher
Chen K, Huang K, Lin C, Weng W, Hsu L, Goto S, et al. MicroRNA-27b Enhances the Hepatic Regenerative Properties of Adipose-Derived Mesenchymal Stem Cells. Mol Ther Nucleic Acids. 2016;5:e285 pubmed publisher
Aggarwal S, Lam A, Bolisetty S, Carlisle M, Traylor A, Agarwal A, et al. Heme Attenuation Ameliorates Irritant Gas Inhalation-Induced Acute Lung Injury. Antioxid Redox Signal. 2016;24:99-112 pubmed publisher
Song J, Li P, Chaudhary N, Gemmete J, Thompson B, Xi G, et al. Correlating Cerebral (18)FDG PET-CT Patterns with Histological Analysis During Early Brain Injury in a Rat Subarachnoid Hemorrhage Model. Transl Stroke Res. 2015;6:290-5 pubmed publisher
Kawashiri M, Nakanishi C, Tsubokawa T, Shimojima M, Yoshida S, Yoshimuta T, et al. Impact of Enhanced Production of Endogenous Heme Oxygenase-1 by Pitavastatin on Survival and Functional Activities of Bone Marrow-derived Mesenchymal Stem Cells. J Cardiovasc Pharmacol. 2015;65:601-6 pubmed publisher
Huang H, Hong L, Chang P, Zhang J, Lü S, Zheng B, et al. Chitooligosaccharides attenuate Cu2+-induced cellular oxidative damage and cell apoptosis involving Nrf2 activation. Neurotox Res. 2015;27:411-20 pubmed publisher
Cremers N, Lundvig D, van Dalen S, Schelbergen R, van Lent P, Szarek W, et al. Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells. Int J Mol Sci. 2014;15:17974-99 pubmed publisher
Lundvig D, Scharstuhl A, Cremers N, Pennings S, Te Paske J, van Rheden R, et al. Delayed cutaneous wound closure in HO-2 deficient mice despite normal HO-1 expression. J Cell Mol Med. 2014;18:2488-98 pubmed publisher
Wang L, Chiou S, Shen Y, Yen F, Ding H, Wu M. Anti-inflammatory effect and mechanism of the green fruit extract of Solanum integrifolium Poir. Biomed Res Int. 2014;2014:953873 pubmed publisher
Yamashita Y, Ueyama T, Nishi T, Yamamoto Y, Kawakoshi A, Sunami S, et al. Nrf2-inducing anti-oxidation stress response in the rat liver--new beneficial effect of lansoprazole. PLoS ONE. 2014;9:e97419 pubmed publisher
Busnelli M, Manzini S, Froio A, Vargiolu A, Cerrito M, Smolenski R, et al. Diet induced mild hypercholesterolemia in pigs: local and systemic inflammation, effects on vascular injury - rescue by high-dose statin treatment. PLoS ONE. 2013;8:e80588 pubmed publisher
Zhang T, Liang X, Shi L, Wang L, Chen J, Kang C, et al. Estrogen receptor and PI3K/Akt signaling pathway involvement in S-(-)equol-induced activation of Nrf2/ARE in endothelial cells. PLoS ONE. 2013;8:e79075 pubmed publisher
Adolph T, Tomczak M, Niederreiter L, Ko H, Böck J, Martínez Naves E, et al. Paneth cells as a site of origin for intestinal inflammation. Nature. 2013;503:272-6 pubmed publisher
Hull T, Bolisetty S, Dealmeida A, Litovsky S, Prabhu S, Agarwal A, et al. Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase. Lab Invest. 2013;93:868-79 pubmed publisher
Cunnington A, Njie M, Correa S, Takem E, Riley E, Walther M. Prolonged neutrophil dysfunction after Plasmodium falciparum malaria is related to hemolysis and heme oxygenase-1 induction. J Immunol. 2012;189:5336-46 pubmed publisher
Kongpetch S, Kukongviriyapan V, Prawan A, Senggunprai L, Kukongviriyapan U, Buranrat B. Crucial role of heme oxygenase-1 on the sensitivity of cholangiocarcinoma cells to chemotherapeutic agents. PLoS ONE. 2012;7:e34994 pubmed publisher
Stoeger T, Takenaka S, Frankenberger B, Ritter B, Karg E, Maier K, et al. Deducing in vivo toxicity of combustion-derived nanoparticles from a cell-free oxidative potency assay and metabolic activation of organic compounds. Environ Health Perspect. 2009;117:54-60 pubmed publisher
Kartikasari A, Wagener F, Yachie A, Wiegerinck E, Kemna E, Swinkels D, et al. Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency. J Cell Mol Med. 2009;13:3091-102 pubmed publisher
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.