PD-1 (human), (recombinant) | Enzo Life Sciences ENZ-PRT190-0050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

PD-1 (human), (recombinant)

catalog :

ENZ-PRT190-0050

quantity :

50 µg

product information

Product ID :

ENZ-PRT190

Catalog Number :

ENZ-PRT190-0050

Product Name :

PD-1 (human), (recombinant)

Product Type :

Protein

Size :

50 µg

Image Legend 4 :

PD-1 Activity. PD-1 activity is in the range of 100 – 25,000 ng/ml. This was done by measuring PD-1’s ability to bind to human PD-L1 (B7-H1) that was immobilized onto magnetic beads. Briefly, PD-1 was titered into the assay, which contained PD-L1 coated magnetic beads and goat anti – human PD-1 conjugated to phycoerythrin (PE). The reactions were incubated for 1 hour at room temperature, washed 3X with PBS, and resuspended in PBS. Each reaction was analyzed by measuring median PE intensity on a BD FacsCalibur cytometer.

Background :

PD-1 (programmed cell death-1) is a transmembrane protein important for regulating immune responses. It is a member of the CD28/CTLA-4 family of immunoreceptors and is expressed on T cells and pro-B cells suggesting it has a broad spectrum of immune regulation. PD-1 along with its two ligands, PD-L1 and PD-L2, prevent the activation of T cells and protect tissues from autoimmune attack. PD-1 and its ligands are also involved in reduction of infectious immunity, as well as tumor immunity. PD-1 has been shown to facilitate chronic infection and tumor progression. Drugs targeting PD-1 have shown promise in treating cancer and HIV and may be important in a variety of immune related disorders.

ALTnames :

Programmed cell death-1, CD279

Purity :

≥90% (SDS-PAGE)

Buffer :

Lyophilized

Storage :

-20°C