This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
ELISA/assay
product name :
Proinsulin ELISA kit
catalog :
ENZ-KIT149-0001
quantity :
96 wells
product information
Product ID :
ENZ-KIT149
Catalog Number :
ENZ-KIT149-0001
Product Name :
Proinsulin ELISA kit
Product Type :
Kit
Size :
96 wells
Product Description :
The Proinsulin ELISA kit is a colorimetric immunometric immunoassay kit with results in 3 hours.
SPECIES REACTIVITY :
Human
Background :
Type 2 diabetes mellitus is the most common serious metabolic condition in the world, and results from a subnormal response of tissues to insulin (insulin resistance) and a failure of the insulin-secreting beta cells to compensate. Insulin is required for glucose homeostasis and an important precursor protein to insulin is proinsulin. Proinsulin is composed of the A and B subunits of insulin and is connected by the C-peptide region. This 10.5 kDa protein, which contains 110 amino acids, is synthesized as a single chain that contains a 24 amino acid signal sequence and an 86 amino acid proinsulin propeptide. Proinsulin is processed in the endoplasmic reticulum of pancreatic β-cells and is converted within immature secretory granules into insulin and C-peptide. While mature insulin is required for glucose homeostasis and C-peptide is associated with renal function, proinsulin has low metabolic activity. However, it is biologically active and is a regulator of development in prepancreatic embryonic stages. The release of proinsulin is significantly increased in patients with type 2 diabetes as well as in individuals with impaired glucose tolerance (IGT). The levels of proinsulin can also increase with age.
Uses :
For the quantitative determination of proinsulin in human serum and plasma samples.
Application Summary :
ELISA, Colorimetric detection
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.