product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Melanoma marker (human) monoclonal antibody (HMB45)
catalog :
ENZ-C34930
quantity :
0.5 ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HMB45
reactivity :
human
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
Enzo Life Sciences product webpage
citations: 24
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 1b
Ho T, WATT B, Spruce L, Seeholzer S, Marks M. The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation. J Biol Chem. 2016;291:3595-612 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Riesenberg S, Groetchen A, Siddaway R, Bald T, Reinhardt J, Smorra D, et al. MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Nat Commun. 2015;6:8755 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
Agaimy A, Specht K, Stoehr R, Lorey T, Märkl B, Niedobitek G, et al. Metastatic Malignant Melanoma With Complete Loss of Differentiation Markers (Undifferentiated/Dedifferentiated Melanoma): Analysis of 14 Patients Emphasizing Phenotypic Plasticity and the Value of Molecular Testing as Surrogate Diagnostic Marker. Am J Surg Pathol. 2016;40:181-91 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 3
Ohlmann C, Brecht I, Junker K, van der Zee J, Nistor A, Bohle R, et al. Sclerosing epithelioid fibrosarcoma of the kidney: clinicopathologic and molecular study of a rare neoplasm at a novel location. Ann Diagn Pathol. 2015;19:221-5 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
Büttner M, Kufer V, Brunner K, Hartmann A, Amann K, Agaimy A. Benign mesenchymal tumours and tumour-like lesions in end-stage renal disease. Histopathology. 2013;62:229-36 pubmed publisher
  • immunohistochemistry; human; 1:50
Yamada Y, Yamamoto H, Ohishi Y, Nishiyama K, Fukuhara M, Saitou T, et al. Sclerosing variant of perivascular epithelioid cell tumor in the female genital organs. Pathol Int. 2011;61:768-72 pubmed publisher
Yamada S, Nawata A, Yoshioka M, Hiraki T, Higashi M, Hatanaka K, et al. Complete regression of primary cutaneous malignant melanoma associated with distant lymph node metastasis: a teaching case mimicking blue nevus. BMC Res Notes. 2016;9:366 pubmed publisher
Rothermel L, Sabesan A, Stephens D, Chandran S, Paria B, Srivastava A, et al. Identification of an Immunogenic Subset of Metastatic Uveal Melanoma. Clin Cancer Res. 2016;22:2237-49 pubmed publisher
Insabato L, Guadagno E, Natella V, Somma A, Bihl M, Pizzolorusso A, et al. An unusual association of malignant gastrointestinal neuroectodermal tumor (clear cell sarcoma-like) and Ewing sarcoma. Pathol Res Pract. 2015;211:688-92 pubmed publisher
Lee B, Sukri N, Ogden H, Vine C, Thake C, Turner J, et al. A comparison of two commercially available ELISA methods for the quantification of human plasma heat shock protein 70 during rest and exercise stress. Cell Stress Chaperones. 2015;20:917-26 pubmed publisher
Rabban J, Firetag B, Sangoi A, Post M, Zaloudek C. Incidental Pelvic and Para-aortic Lymph Node Lymphangioleiomyomatosis Detected During Surgical Staging of Pelvic Cancer in Women Without Symptomatic Pulmonary Lymphangioleiomyomatosis or Tuberous Sclerosis Complex. Am J Surg Pathol. 2015;39:1015-25 pubmed publisher
Yamada S, Nabeshima A, Noguchi H, Nawata A, Nishii H, Guo X, et al. Coincidence between malignant perivascular epithelioid cell tumor arising in the gastric serosa and lung adenocarcinoma. World J Gastroenterol. 2015;21:1349-56 pubmed publisher
Kasraee B, Nikolic D, Salomon D, Carraux P, Fontao L, Piguet V, et al. Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer. Exp Dermatol. 2012;21:19-24 pubmed publisher
Kasraee B, Pataky M, Nikolic D, Carraux P, Piguet V, Salomon D, et al. A new spectrophotometric method for simple quantification of melanosomal transfer from melanocytes to keratinocytes. Exp Dermatol. 2011;20:938-42 pubmed publisher
Helmke B, Zahel T, Breinig M, Schirmacher P, Aulmann S, Kern M. Her2 overexpression is a rare event in anorectal melanoma. Melanoma Res. 2010;20:431-4 pubmed publisher
Kamino H, Tam S, Roses D, Toussaint S. Elastic fiber pattern in regressing melanoma: a histochemical and immunohistochemical study. J Cutan Pathol. 2010;37:723-9 pubmed publisher
Ryan P, Nguyen V, Gholoum S, Carpineta L, Abish S, Ahmed N, et al. Polypoid PEComa in the rectum of a 15-year-old girl: case report and review of PEComa in the gastrointestinal tract. Am J Surg Pathol. 2009;33:475-82 pubmed publisher
North J, Kageshita T, Pinkel D, LeBoit P, Bastian B. Distribution and significance of occult intraepidermal tumor cells surrounding primary melanoma. J Invest Dermatol. 2008;128:2024-30 pubmed publisher
Raposo G, Tenza D, Murphy D, Berson J, Marks M. Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells. J Cell Biol. 2001;152:809-24 pubmed
Gown A, Vogel A, Hoak D, Gough F, McNutt M. Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes. Am J Pathol. 1986;123:195-203 pubmed
Wick M, Stanley S, Swanson P. Immunohistochemical diagnosis of sinonasal melanoma, carcinoma, and neuroblastoma with monoclonal antibodies HMB-45 and anti-synaptophysin. Arch Pathol Lab Med. 1988;112:616-20 pubmed
Duray P, Palazzo J, Gown A, Ohuchi N. Melanoma cell heterogeneity. A study of two monoclonal antibodies compared with S-100 protein in paraffin sections. Cancer. 1988;61:2460-8 pubmed
Wick M, Swanson P, Rocamora A. Recognition of malignant melanoma by monoclonal antibody HMB-45. An immunohistochemical study of 200 paraffin-embedded cutaneous tumors. J Cutan Pathol. 1988;15:201-7 pubmed
Ordonez N, Ji X, Hickey R. Comparison of HMB-45 monoclonal antibody and S-100 protein in the immunohistochemical diagnosis of melanoma. Am J Clin Pathol. 1988;90:385-90 pubmed
product information
Product ID :
ENZ-C34930
Catalog Number :
ENZ-C34930
Product Name :
Melanoma marker (human) monoclonal antibody (HMB45)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
0.5 ml
list of Pubmed id :
25990776, 25632212, 3518473, 3377660, 3365669, 3053811, 2459952
Clone :
HMB45
Isotype :
IgG1
SPECIES REACTIVITY :
Human
Immunogen :
Human axillary lymph node tissue containing pigmnted melanoma metastases.
Specificity :
Recognizes a human melanoma-specific antigen present in melanocytic cells and junctional nevi. Does not cross-react with normal melanocytes, intradermal nevus cells or other neoplasms including sarcomas, carcinomas and glial tumors.
Buffer :
Liquid. In PBS containing 0.1% sodium azide and 1% BSA.
Application Summary :
IHC (PS)
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.