This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Cardif/MAVS (human) monoclonal antibody (58N3B6)
catalog :
ENZ-ABS259-0100
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
58N3B6

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry
citations: 1
Reference
Chiba Y, Matsumiya T, Satoh T, Hayakari R, Furudate K, Xing F, et al. Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5. Biochem Biophys Res Commun. 2015;467:191-6 pubmed publisher
product information
Product ID :
ENZ-ABS259
Catalog Number :
ENZ-ABS259-0100
Product Name :
Cardif/MAVS (human) monoclonal antibody (58N3B6)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
list of Pubmed id :
26454171
Clone :
58N3B6
Isotype :
IgG2bκ
SPECIES REACTIVITY :
Human
Background :
RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-κB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-κB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-β production.
ALTnames :
CARD adapter inducing interferon-β, IPS-1, Interferon-β promoter stimulator protein 1, Mitochondrial antiviral signalling protein, VISA, Virus-induced signalling adapter
Immunogen :
Human MAVS (IPS-1)
Buffer :
Liquid. In 0.2ml PBS containing 0.05% BSA and 0.05% sodium azide.
Application Summary :
IHC (PS), WB
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.