Gliadin peptide monoclonal antibody (14D5) | Enzo Life Sciences BPD-HYB-314-01-02 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Gliadin peptide monoclonal antibody (14D5)

catalog :

BPD-HYB-314-01-02

quantity :

200 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

14D5

product information

Product ID :

BPD-HYB-314-01

Catalog Number :

BPD-HYB-314-01-02

Product Name :

Gliadin peptide monoclonal antibody (14D5)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

200 µg

Clone :

14D5

Isotype :

IgG2aλ

SPECIES REACTIVITY :

Plant

Background :

Celiac disease is associated with a CD4+ T-cell response to epitopes of gliadin presented by HLA-DQ2 or -DQ8 class II MHC molecules. These epitopes are present in a 33-mer peptide of wheat alpha-gliadin, residues 56-88, which is resistant to digestion and forms a substrate for tissue transglutaminase (TG2), generating the glutamic acid residues essential for binding to HLA-DQ2. The immunogen corresponds to a deamidated form of a region that includes the T-cell epitopes, including the immunodominant PQPQLPY region and two PXPQP motifs associated with binding to IgA from patients with celiac disease. Complete homology exists between residues 63-73, 70-80 and 77-87 of wheat alpha gliadin.

ALTnames :

alpha Gliadin

Immunogen :

Synthetic peptide corresponding to aa Lys57-Glu65-[α-gliadin (58-73)] (KLQPFPQPELPYPQPQ) of Gliadin-related peptide.

Buffer :

Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide.

Uses :

Detects a band of ~6 to 10kDa by Western blot.

Application Summary :

ELISA