product summary
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company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Complement component C5b-9 (human) monoclonal antibody (aE11)
catalog :
BPD-DIA-011-01-1
quantity :
1 mg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
aE11
reactivity :
African green monkey, human
application :
ELISA, immunohistochemistry, immunohistochemistry - frozen section
more info or order :
Enzo Life Sciences product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; African green monkey; loading ...; fig 2d
  • ELISA; African green monkey; loading ...; fig 2c
Keshari R, Silasi R, Popescu N, Patel M, Chaaban H, Lupu C, et al. Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis. Proc Natl Acad Sci U S A. 2017;: pubmed publisher
product information
Product ID :
BPD-DIA-011-01
Catalog Number :
BPD-DIA-011-01-1
Product Name :
Complement component C5b-9 (human) monoclonal antibody (aE11)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
1 mg
Clone :
aE11
Isotype :
IgG2aκ
SPECIES REACTIVITY :
Human
Background :
C5b-9, also known as the terminal complement complex (TCC), consists of C5b, C6, C7, C8 and C9, and it forms the membrane attack complex (MAC) as well as the non-lytic fluid-phase SC5b-9 complex (with protein S). The MAC forms channels in target cell membranes leading to cell lysis by osmotic leakage. The complexes contain neoantigens absent from the individual native components from which they are formed, and the antibody is directed against a neoepitope exposed on C9 when incorporated into the TCC.
ALTnames :
Terminal complement complex, TCC
Immunogen :
Purified human complement component C5b-9.
Buffer :
Liquid. In 10mM phosphate buffer, pH 7.4, containing 0.15M sodium chloride and 0.09% sodium azide.
Application Summary :
ELISA, IHC
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.