IκBα (human), (recombinant) (GST-tag) | Enzo Life Sciences BML-UW9970-0050 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

IκBα (human), (recombinant) (GST-tag)

catalog :

BML-UW9970-0050

quantity :

50 µg

product information

Product ID :

BML-UW9970

Catalog Number :

BML-UW9970-0050

Product Name :

IκBα (human), (recombinant) (GST-tag)

Product Type :

Protein

Size :

50 µg

Background :

IκBa inhibits activation of the NF-κB pathway activation by associating with the major NF-κB heterodimeric complex p50/p65 and preventing its translocation from the cytoplasm into the nucleus, where it acts a transcription factor for genes involved in inflammation, autoimmune response, cell proliferation, and apoptosis. Inhibition of NF-κB pathway activation by IκBa is controlled by its sequential serine-phosphorylation, ubiquitination and proteasomal degradation. This process itself can be inhibited by SUMOylation of IκBa, providing an additional regulatory step for the activation of the NF-κB pathway.

Purity :

≥95% (SDS-PAGE)

Buffer :

Liquid. In 50mM HEPES, pH 7.5, 200mM NaCl, 1mM DTT.

Uses :

Uses:. 1. NF-κB pathway studies, inhibition of NF-κB p50/p65, substrate for IκB kinase (IKK). 2.Investigation of IκBa phosphorylation/ubiquitinylation/SUMOylation. 3. Ubiquitin-proteasome mediated degradation studies. 4.GST pull down of IκBa interacting partners

Storage :

-80°C