UCH-L1 (human), (recombinant) (His-tag) | Enzo Life Sciences BML-UW9740-0050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

UCH-L1 (human), (recombinant) (His-tag)

catalog :

BML-UW9740-0050

quantity :

50 µg

product information

Product ID :

BML-UW9740

Catalog Number :

BML-UW9740-0050

Product Name :

UCH-L1 (human), (recombinant) (His-tag)

Product Type :

Protein

Size :

50 µg

Background :

Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters and thioesters of the C-terminus of ubiquitin. Mammalian neuronal cells abundantly express a deubiquitylating enzyme, ubiquitin carboxy-terminal hydrolase 1 (UCH-L1). Mutations in UCH-L1 are linked to Parkinson's disease as well as gracile axonal dystrophy (gad) in mice. In contrast to the universally expressed UCH-L3 isozyme, UCH-L1 is expressed exclusively in neurons and testis/ovary. It has been shown that UCH-L1 associates and co-localizes with monoubiquitin and elongates ubiquitin half-life and the suggestion is made that UCH-L1, with avidity and affinity for ubiquitin, ensures ubiquitin stability within neurons.

ALTnames :

Ubiquitin C-terminal hydrolase L1, PGP9.5

Buffer :

Liquid. In 50 mM TRIS, pH 7.6, containing 1 mM dithiothreitol (DTT).

Storage :

-80°C