This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
protein
product name :
hHR6A (human), (recombinant) (His-tag)
catalog :
BML-UW9635-0100
quantity :
100 µg
product information
Product ID :
BML-UW9635
Catalog Number :
BML-UW9635-0100
Product Name :
hHR6A (human), (recombinant) (His-tag)
Product Type :
Protein
Size :
100 µg
Product Description :
Ubiquitin-conjugating DNA repair enzyme.
Background :
The family of UBC enzymes plays a central role in the ubiquitin pathway. Genetic studies with the S.cerevisiae Rad6 protein demonstrate a pleiotropic phenotype, including defects in DNA repair, proteolysis of N-end rule protein substrates, cellular proliferation, cell cycle progression and an inability to sporulate, which are all dependent on its ubiquitin-conjugating activity. Rad6 can ubiquitinylate histones in vitro, and ubiquitinylation of histone H2B in S. cerevisiae is Rad6 dependent. In mice and humans, two homologues of RAD6 have been identified - hHR6A (homologue of RAD6A) and hHR6B (homologue of RAD6B). UbcH2A is phosphorylated in vitro by CDK-1 and -2 on serine residue 120, which is conserved in all hHR6A homologs, leading to an increase in the ubiquitin-conjugating activity of this enzyme.
ALTnames :
UbcH2A, Ubiquitin conjugating enzyme E2 A
Buffer :
Liquid. In 50mM HEPES, pH 8.0, containing 50mM sodium chloride, 10% glycerol and 1mM DTT.
Storage :
-80°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.