Otubain-1 (human), (recombinant) (His-tag) | Enzo Life Sciences BML-UW0680-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

Otubain-1 (human), (recombinant) (His-tag)

catalog :

BML-UW0680-0100

quantity :

100 µg

product information

Product ID :

BML-UW0680

Catalog Number :

BML-UW0680-0100

Product Name :

Otubain-1 (human), (recombinant) (His-tag)

Product Type :

Protein

Size :

100 µg

Background :

Otubain-1 belongs to the ovarian tumor (OTU) domain class of cysteine protease deubiquitinating enzymes and has been implicated in mediating lymphocyte antigen responsiveness and may be generally involved in RNA processing and cell adhesion/morphology. Human otubain-1 has been shown to exhibit high linkage-specificity in vitro, cleaving Lys48 (K48)-linked polyubiquitin but not K63-, K29-, K6-, or K11-linked polyubiquitin, or linear α-linked polyubiquitin. Cleavage is not limited to either end of a polyubiquitin chain, and both free and substrate-linked polyubiquitin are disassembled.

ALTnames :

OTUB1, Ubiquitin thioesterase OTUB1, Ubiquitin-specific-processing protease OTUB1, Deubiquitinating enzyme OTUB1

Purity :

≥95% (SDS-PAGE)

Buffer :

Liquid. In 50mM TRIS, pH 7.5, containing 50mM NaCl and 1mM DTT.

Uses :

Uses:. 1. Deubiquitinylation assays using polyubiquitin chains or ubiquitin-protein conjugates. 2. Studies of the K48-linkage specific polyubiquitin chain binding and deubiquitinylation. 3. Investigation of the role of Otubain-1 in various biological processes. 4. Development of inhibitors for Otubain-1 deubiquitinylating activity.

Storage :

-80°C