USP25 (isoform 2) (human), (recombinant) (His-tag) | Enzo Life Sciences BML-UW0475-0050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

USP25 (isoform 2) (human), (recombinant) (His-tag)

catalog :

BML-UW0475-0050

quantity :

50 µg

citations: 1

Reference
Zlatanou A, Sabbioneda S, Miller E, Greenwalt A, Aggathanggelou A, Maurice M, et al. USP7 is essential for maintaining Rad18 stability and DNA damage tolerance. Oncogene. 2016;35:965-76 pubmed publisher

product information

Product ID :

BML-UW0475

Catalog Number :

BML-UW0475-0050

Product Name :

USP25 (isoform 2) (human), (recombinant) (His-tag)

Product Type :

Protein

Size :

50 µg

list of Pubmed id :

25961918

Background :

Ubiquitin specific protease-25 (USP25) is a vertebrate specific deubiquitinating enzyme. Three alternative splice variants have been identified; two ubiquitously expressed and one, the longer isoform USP25m, restricted to expression in muscular tissues where it is upregulated during myogenesis. Whilst its biological function and regulation have yet to be fully elucidated, increased USP25 expression levels have been observed in Down syndrome fetal brains and in breast cancer tissue. USP25 is also a target for SUMO modification, which takes place within its two ubiquitin intreaction motifs and has been shown to impair it’s binding to and hydrolysis of polyubiquitin chains.

ALTnames :

Ubiquitin thioesterase 25, Ubiquitin-specific protease 25, Deubiquitinating enzyme 25, USP on chromosome 21

Purity :

≥95% (SDS-PAGE)

Buffer :

Liquid. In 50mM TRIS, pH 8.0, containing 50mM NaCl and 1mM DTT.

Uses :

Uses:. 1. Deubiquitinylation assays using small molecule substrates (e.g. Ub-AMC, Prod. No. BML-SE211) or ubiquitin-protein conjugates. 2. Studies of the effect of SUMO modification on USP25 activity. 3. Investigation of the role of USP25 in various biological processes. 4. Development of inhibitors for USP25 deubiquitinylating activity.

Storage :

-80°C