This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
protein
product name :
SUMO-2 aldehyde
catalog :
BML-UW0065-0025
quantity :
25 µg
product information
Product ID :
BML-UW0065
Catalog Number :
BML-UW0065-0025
Product Name :
SUMO-2 aldehyde
Product Type :
Protein
Size :
25 µg
Product Description :
Inhibitor of deSUMOylating enzymes (SENPs). SUMO-2 aldehyde is a highly specific inhibitor of SENP enzymes and has utility in the stabilisation of SUMO-protein conjugates in vitro, enhancing their accumulation in cell lysates and tissue extracts. In addition, co-crystallisation of yeast SUMO (Smt3) aldehyde with the yeast deSUMOylating enzyme Ulp1 has been used to probe the enzyme: substrate interactions, so human SUMO-aldehydes may therefore be of similar utility, and SUMO-2 aldehyde may be used in conjunction with SUMO-1 aldehyde (Prod. No. BML-UW0060) to probe the SUMO paralogue preference of SENP enzymes.
Background :
SUMO proteases (SENPs) contribute to three distinct activities in the cell, processing SUMO precursors to generate mature SUMO, depolymerization of SUMO chains, and deconjugation of SUMO modified proteins. Cleavage occurs after the conserved SUMO Gly-Gly motif either at the scissile peptide bond during processing or at the scissile isopeptide bond during depolymerization and deconjugation. The six human SUMO specific SENP enzymes (1-3, 5-7), have been shown to participate in non-redundant cellular functions such as HIF1-α stabilization during hypoxia, mitosis and cytokinesis.
ALTnames :
Sentrin-2 aldehyde
Purity :
≥95% (HPLC)
Buffer :
Liquid. In 0.15M HCl.
Uses :
Suggested uses: Stabilisation of SUMO-protein conjugates in cell lysates and tissue extracts. Determination of inhibition kinetics for specific deSUMOylating enzymes. Co-crystallisation with specific deSUMOylating enzymes for structural studies Probe for investigating enzyme:substrate interactions. Used in conjunction with SUMO-1 aldehyde (Prod. No. BML-UW0060) to probe the SUMO paralogue preference of SENP enzymes
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.