This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Latrunculin B
catalog :
BML-T110-0001
quantity :
1 mg
citations: 15
Reference
Yang J, Chi W, Liang J, Takayanagi S, Iglesias P, Huang C. Deciphering cell signaling networks with massively multiplexed biosensor barcoding. Cell. 2021;184:6193-6206.e14 pubmed publisher
Ho W, Tai Y, Chang J, Liang J, Tyan S, Chen S, et al. The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy. Autophagy. 2019;15:827-842 pubmed publisher
Yang J, Bhattacharya S, West Foyle H, Hung C, Wu T, Iglesias P, et al. Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation. Nat Commun. 2018;9:4673 pubmed publisher
Ege N, Dowbaj A, Jiang M, Howell M, Hooper S, Foster C, et al. Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export. Cell Syst. 2018;6:692-708.e13 pubmed publisher
Zhu C, Ganguly A, Baskin T, McClosky D, Anderson C, Foster C, et al. The fragile Fiber1 kinesin contributes to cortical microtubule-mediated trafficking of cell wall components. Plant Physiol. 2015;167:780-92 pubmed publisher
Stanganello E, Hagemann A, Mattes B, Sinner C, Meyen D, Weber S, et al. Filopodia-based Wnt transport during vertebrate tissue patterning. Nat Commun. 2015;6:5846 pubmed publisher
Allam R, Darisipudi M, Tschopp J, Anders H. Histones trigger sterile inflammation by activating the NLRP3 inflammasome. Eur J Immunol. 2013;43:3336-42 pubmed publisher
Arif E, Wagner M, Johnstone D, Wong H, George B, Pruthi P, et al. Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane. Mol Cell Biol. 2011;31:2134-50 pubmed publisher
Minamide L, Maiti S, Boyle J, Davis R, Coppinger J, Bao Y, et al. Isolation and characterization of cytoplasmic cofilin-actin rods. J Biol Chem. 2010;285:5450-60 pubmed publisher
Cha B, Kenworthy A, Murtazina R, Donowitz M. The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP. J Cell Sci. 2004;117:3353-65 pubmed
Wakatsuki T, Schwab B, Thompson N, Elson E. Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J Cell Sci. 2001;114:1025-36 pubmed
Spector I, Shochet N, Kashman Y, Groweiss A. Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells. Science. 1983;219:493-5 pubmed
Schatten G, Schatten H, Spector I, Cline C, Paweletz N, Simerly C, et al. Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice. Exp Cell Res. 1986;166:191-208 pubmed
Coue M, Brenner S, Spector I, Korn E. Inhibition of actin polymerization by latrunculin A. FEBS Lett. 1987;213:316-8 pubmed
de Oliveira C, Mantovani B. Latrunculin A is a potent inhibitor of phagocytosis by macrophages. Life Sci. 1988;43:1825-30 pubmed
product information
Product ID :
BML-T110
Catalog Number :
BML-T110-0001
Product Name :
Latrunculin B
Product Type :
Biochemical
Size :
1 mg
list of Pubmed id :
25646318, 25556612, 23964013, 20022956, 15226406, 11181185, 6681676, 3743654, 3556584, 3200109
Product Description :
Structurally unique marine toxin. Actin filament modulator. 10- to 100-fold more potent than cytochalasins. Whereas cytochalasin D (Prod. No. BML-T109) induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture, latrunculin B causes a shortening and thickening of stress fibers. Effects on N1E-115 cells (mouse neuroblastoma) at concentrations as low as 90nM (NI43T3 cells, 0.9µM). Maximum effects at 2.5µM. Slowly inactivated by fetal bovine serum. Inhibition of cofilin-actin binding (ED50~50µM)
Purity :
≥98% (HPLC)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.