LY 294002 | Enzo Life Sciences BML-ST420-0025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

LY 294002

catalog :

BML-ST420-0025

quantity :

25 mg

citations: 10

Reference
Kim J, Jeong M, Kim D, Her S, Wie M. Zinc oxide nanoparticles induce lipoxygenase-mediated apoptosis and necrosis in human neuroblastoma SH-SY5Y cells. Neurochem Int. 2015;90:204-14 pubmed publisher
Cho W, Kang J, Park Y. Corticotropin-Releasing Hormone (CRH) Promotes Macrophage Foam Cell Formation via Reduced Expression of ATP Binding Cassette Transporter-1 (ABCA1). PLoS ONE. 2015;10:e0130587 pubmed publisher
Mena H, Lokajczyk A, Dizier B, Strier S, Voto L, Boisson Vidal C, et al. Acidic preconditioning improves the proangiogenic responses of endothelial colony forming cells. Angiogenesis. 2014;17:867-79 pubmed publisher
Wu M, Obara Y, Norota I, Nagasawa Y, Ishii K. Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require ?-subunit KCNE1. Pflugers Arch. 2014;466:937-46 pubmed publisher
Rohatgi N, Aly H, Marshall C, McDonald W, Kletzien R, Colca J, et al. Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. PLoS ONE. 2013;8:e62012 pubmed publisher
Yadav V, Denning M. Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration. Mol Carcinog. 2011;50:346-52 pubmed publisher
Graham J, Hendershott M, Terragni J, Cooper G. mRNA degradation plays a significant role in the program of gene expression regulated by phosphatidylinositol 3-kinase signaling. Mol Cell Biol. 2010;30:5295-305 pubmed publisher
Inamura Y, Miyamae M, Sugioka S, Domae N, Kotani J. Sevoflurane postconditioning prevents activation of caspase 3 and 9 through antiapoptotic signaling after myocardial ischemia-reperfusion. J Anesth. 2010;24:215-24 pubmed publisher
Santos A, Bakker A, Zandieh Doulabi B, de Blieck Hogervorst J, Klein Nulend J. Early activation of the beta-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase. Biochem Biophys Res Commun. 2010;391:364-9 pubmed publisher
Hayakawa M, Kawaguchi K, Kaizawa H, Koizumi T, Ohishi T, Yamano M, et al. Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem. 2007;15:5837-44 pubmed

product information

Product ID :

BML-ST420

Catalog Number :

BML-ST420-0025

Product Name :

LY 294002

Product Type :

Biochemical

Size :

25 mg

list of Pubmed id :

26364578, 26110874, 24854678, 24068254, 23650507, 21480388, 20855526, 20177944, 19913504, 17601739

Product Description :

Potent, cell permeable, inhibitor of PI(3)K (phosphoinositide 3-kinase) that acts on the ATP-binding site of the enzyme. Displays an IC50 of 1.4µM and inhibits all isoforms equally in in vitro assays using purified PI 3-kinase (p110α IC50=0.63µM). Inhibits Pim-1 kinase with IC50=4.0µM. Other kinases such as PKC, PKA, MAP kinase, S6 kinase, EGF receptor tyrosine kinase, c-src kinase, PI 4-kinase, diacylglycerol kinase or rabbit kidney ATPase are not inhibited at 50µM. Induces apoptosis in many cell types by blocking the PI3-K/Akt anti-apoptotic pathway. Useful tool for identifying cellular events which are regulated by the PI3-K/Akt axis. Sensitizes tumor cells to drug-induced apoptosis independent of its PI3K inhibitory activity. Inhibits proliferation and induces apoptosis in human colon cancer cells. Suppresses proliferation of mouse embryonic stem cells. Furthermore, inhibits autophagic sequestration in rat hepatocytes.

ALTnames :

2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

Purity :

≥98% (HPLC)

Storage :

-20°C