This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Wortmannin
catalog :
BML-ST415-0020
quantity :
20 mg
citations: 11
Reference
Moscariello M, Wieloch R, Kurosawa A, Li F, Adachi N, Mladenov E, et al. Role for Artemis nuclease in the repair of radiation-induced DNA double strand breaks by alternative end joining. DNA Repair (Amst). 2015;31:29-40 pubmed publisher
Manganaro D, Consonni A, Guidetti G, Canobbio I, Visconte C, Kim S, et al. Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl. Biochim Biophys Acta. 2015;1853:1879-88 pubmed publisher
Galindo I, Cuesta Geijo M, Hlavova K, Muñoz Moreno R, Barrado Gil L, Dominguez J, et al. African swine fever virus infects macrophages, the natural host cells, via clathrin- and cholesterol-dependent endocytosis. Virus Res. 2015;200:45-55 pubmed publisher
Yang C, Kuai X, Li Y, Zhang L, Yu J, Li L, et al. Cornel Iridoid Glycoside Attenuates Tau Hyperphosphorylation by Inhibition of PP2A Demethylation. Evid Based Complement Alternat Med. 2013;2013:108486 pubmed publisher
Crivat G, Lizunov V, Li C, Stenkula K, Zimmerberg J, Cushman S, et al. Insulin stimulates translocation of human GLUT4 to the membrane in fat bodies of transgenic Drosophila melanogaster. PLoS ONE. 2013;8:e77953 pubmed publisher
Wilson A, Liu A, ROLAND J, Adebayo O, Fletcher S, Slaughter J, et al. TR3 modulates platinum resistance in ovarian cancer. Cancer Res. 2013;73:4758-69 pubmed publisher
Basile V, Belluti S, Ferrari E, Gozzoli C, Ganassi S, Quaglino D, et al. bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS ONE. 2013;8:e53664 pubmed publisher
Chiang W, Huang C, Llanora G, Gerez I, Goh S, Shek L, et al. Anaphylaxis to cow's milk formula containing short-chain galacto-oligosaccharide. J Allergy Clin Immunol. 2012;130:1361-7 pubmed publisher
Al Zobaidy M, Craig J, Brown K, Pettifor G, Martin W. Stimulus-specific blockade of nitric oxide-mediated dilatation by asymmetric dimethylarginine (ADMA) and monomethylarginine (L-NMMA) in rat aorta and carotid artery. Eur J Pharmacol. 2011;673:78-84 pubmed publisher
Suh B, Jung J, Park N, Seong C, Im H, Kwon Y, et al. Induction of steroid sulfatase expression by tumor necrosis factor-? through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells. Exp Mol Med. 2011;43:646-52 pubmed publisher
Cho Y, Ahn D, Morgan K, Lee Y. Enhanced contractility and myosin phosphorylation induced by Ca(2+)-independent MLCK activity in hypertensive rats. Cardiovasc Res. 2011;91:162-70 pubmed publisher
product information
Product ID :
BML-ST415
Catalog Number :
BML-ST415-0020
Product Name :
Wortmannin
Product Type :
Biochemical
Size :
20 mg
list of Pubmed id :
25973742, 25960397, 25662020, 24454482, 24223128, 23720056, 23326480, 23102546, 22056836, 21904110
Product Description :
Potent and selective inhibitor of phosphatidyl-inositol 3-kinase. Active in purified preparations and cytosolic fractions(IC50 = 5nM) and is highly cell permeable. Inhibits fMLP induced PIP3 and superoxide anion production (IC50 = 50nM) in guinea pig neutrophils and blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Covalently binds to PI 3-kinase and is selective, inhibiting other kinases such as PI 4-kinase and myosin light chain kinase at concentrations 100-fold higher than that required for inhibition of PI 3-kinase. The half-life of wortmannin in culture media is quite short (8-13 minutes), care should be taken to account for this decomposition when planning experiments. Markedly potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau.
ALTnames :
KY 12420
Purity :
≥98% (HPLC, TLC)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.