This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
AACOCF3
catalog :
BML-ST335-0010
quantity :
10 mg
citations: 6
Reference
Cabral M, Martín Venegas R, Moreno J. Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. Physiol Rep. 2015;3: pubmed publisher
Bartoli F, Lin H, Ghomashchi F, Gelb M, Jain M, Apitz Castro R. Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets. J Biol Chem. 1994;269:15625-30 pubmed
Riendeau D, Guay J, Weech P, Laliberte F, Yergey J, Li C, et al. Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J Biol Chem. 1994;269:15619-24 pubmed
Koutek B, Prestwich G, Howlett A, Chin S, Salehani D, Akhavan N, et al. Inhibitors of arachidonoyl ethanolamide hydrolysis. J Biol Chem. 1994;269:22937-40 pubmed
Street I, Lin H, Laliberte F, Ghomashchi F, Wang Z, Perrier H, et al. Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2. Biochemistry. 1993;32:5935-40 pubmed
Ackermann E, Conde Frieboes K, Dennis E. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem. 1995;270:445-50 pubmed
product information
Product ID :
BML-ST335
Catalog Number :
BML-ST335-0010
Product Name :
AACOCF3
Product Type :
Biochemical
Size :
10 mg
list of Pubmed id :
26216432, 8195211, 8195210, 8083191, 8018213, 7814408
Product Description :
AACOCF3 is a trifluoromethylketone derivative of arachidonic acid. It is a selective inhibitor of human cytosolic PLA2 and Ca2+-independent PLA2 (iPLA2, IC50=15 µM). It is active in intact platelets and U937 cells (IC50=8 µM). It also inhibits fatty acid amide hydrolase (100% at 7.5 µM).
Purity :
≥98% (TLC)
Storage :
-80°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.