TRAIL (soluble) (human), (recombinant) (His-tag) | Enzo Life Sciences BML-SE721-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

TRAIL (soluble) (human), (recombinant) (His-tag)

catalog :

BML-SE721-0100

quantity :

100 µg

citations: 11

Reference
Moriwaki K, Shinzaki S, Miyoshi E. GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation. J Biol Chem. 2011;286:43123-33 pubmed publisher
Chen K, Yeh P, Hsu C, Hsu C, Lu Y, Hsieh H, et al. Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2009;284:11121-33 pubmed publisher
Panaretakis T, Kepp O, Brockmeier U, Tesniere A, Bjorklund A, Chapman D, et al. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J. 2009;28:578-90 pubmed publisher
Shanker A, Brooks A, Tristan C, Wine J, Elliott P, Yagita H, et al. Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody. J Natl Cancer Inst. 2008;100:649-62 pubmed publisher
Méndez E, Aguirre Crespo G, Zavala G, Arias C. Association of the astrovirus structural protein VP90 with membranes plays a role in virus morphogenesis. J Virol. 2007;81:10649-58 pubmed
Hasegawa H, Yamada Y, Komiyama K, Hayashi M, Ishibashi M, Sunazuka T, et al. A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 producti. Blood. 2007;110:1664-74 pubmed
Sun S, Liu X, Zou W, Yue P, Marcus A, Khuri F. The farnesyltransferase inhibitor lonafarnib induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells. J Biol Chem. 2007;282:18800-9 pubmed
Bhattacharyya N, Pechhold K, Shahjee H, Zappala G, Elbi C, Raaka B, et al. Nonsecreted insulin-like growth factor binding protein-3 (IGFBP-3) can induce apoptosis in human prostate cancer cells by IGF-independent mechanisms without being concentrated in the nucleus. J Biol Chem. 2006;281:24588-601 pubmed
Bernal Mizrachi L, Lovly C, Ratner L. The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas. Proc Natl Acad Sci U S A. 2006;103:9220-5 pubmed
Ma Y, Lakshmikanthan V, Lewis R, Kumar M. Sensitization of TRAIL-resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin. Mol Cancer Ther. 2006;5:170-8 pubmed
Hasegawa H, Yamada Y, Komiyama K, Hayashi M, Ishibashi M, Yoshida T, et al. Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells. Blood. 2006;107:679-88 pubmed

product information

Product ID :

BML-SE721

Catalog Number :

BML-SE721-0100

Product Name :

TRAIL (soluble) (human), (recombinant) (His-tag)

Product Type :

Protein

Size :

100 µg

list of Pubmed id :

22027835, 19261616, 19165151, 18445820, 17652389, 17551094, 17493934, 16793770, 16751281, 16432176

SPECIES REACTIVITY :

Human, Mouse

Background :

TRAIL, also called Apo2L, is a member of the tumor necrosis factor family (TNF). In contrast to other family members such as TNFa/TNFR1 and FasL/Fas, TRAIL and its receptors DR4 and DR5 are widely expressed in many human tissues. TRAIL activates rapid apoptosis in many transformed cell lines but not in normal tissues, even though TRAIL and its receptors DR4 and DR5 are expressed on both cell types. A glycophospholipid-anchored cell surface protein designated decoy receptor 1 (DcR1 or TRID) acts as a decoy to inhibit TRAIL signaling. Thus, TRAIL and its signaling pathways may have direct applications in selective tumor cell death and cancer research.

ALTnames :

Apo-2L, TNFSF 10, CD253

Specificity :

Binds to human and mouse TRAIL receptors and human osteoprotegerin (OPG).

Purity :

≥95% (SDS-PAGE)

Buffer :

Liquid. In 10mM Na2HPO4, 2mM KH2PO4, 2.7mM KCl, 500mM NaCl, 10% glycerol, 0.1mM DTT.

Storage :

-80°C