PCSK9 (human), (recombinant) (His-tag) | Enzo Life Sciences BML-SE570-0010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

PCSK9 (human), (recombinant) (His-tag)

catalog :

BML-SE570-0010

quantity :

10 µg

product information

Product ID :

BML-SE570

Catalog Number :

BML-SE570-0010

Product Name :

PCSK9 (human), (recombinant) (His-tag)

Product Type :

Protein

Size :

10 µg

Background :

PCSK9 is a circulating glycosylated serine protease expressed primarily in kidney, liver, cerebellum, and small intestine. In order for secretion to occur, PCSK9 cleaves its own prodomain, which remains associated and largely inhibits further proteolytic activity. The major function of PCSK9 appears to be regulation of circulating cholesterol levels through its binding of the LDL receptor, resulting in degradation of the LDLR. siRNA inhibition of PCSK9 expression lowers plasma PCSK9, apoB, and LDL cholesterol. PCSK9 may also be involved in Alzheimer’s disease due to its requirement for degradation of BACE1. NOTE: There are many polymorphisms in the PCSK9 gene, some of which cause hyper- or hypocholesterolemia.

ALTnames :

Proprotein convertase subtilisin/kexin 9, Narc-1, Neural apoptosis related convertase 1

Purity :

≥97% (SDS-PAGE)

Buffer :

Lyophilized from a 0.2µm filtered solution of PBS, pH 7.4, containing 8% trehalose, 8% mannitol.

Uses :

Can be used for binding studies with LDL/VLDL/ApoE receptor and Annexin A2, to cleave target substrates and to screen for inhibitors that block PCSK9 binding to lipoprotein receptors. Can be used in tissue cultures.