Abl1 (human), (recombinant) (His-tag) | Enzo Life Sciences BML-SE562-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

Abl1 (human), (recombinant) (His-tag)

catalog :

BML-SE562-0005

quantity :

5 µg

product information

Product ID :

BML-SE562

Catalog Number :

BML-SE562-0005

Product Name :

Abl1 (human), (recombinant) (His-tag)

Product Type :

Protein

Size :

5 µg

Background :

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in cell differentiation, cell division, cell adhesion, and stress responses. The c-Abl protein is inhibited by its SH3 domain, and deletion of this domain turns ABL1 into an oncogene. A chromosomal translocation results in the head-to-tail fusion of the BCR and ABL1 genes. This translocation is present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of Abl1 is regulated by CDC2-mediated phosphorylation.

ALTnames :

Abelson murine leukemia viral oncogene homolog 1

Purity :

≥70% (SDS-PAGE)

Buffer :

Liquid. In 50mM sodium phosphate, pH 7.0, containing 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Uses :

Useful tool to study enzyme regulation and kinetics, phosphorylate target substrates, screen for inhibitors.

Storage :

-80°C