LSD1 (human), (recombinant) | Enzo Life Sciences BML-SE544-0050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

LSD1 (human), (recombinant)

catalog :

BML-SE544-0050

quantity :

50 µg

citations: 1

Reference
Sakane C, Ohta H, Shidoji Y. Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry. J Clin Biochem Nutr. 2015;56:123-31 pubmed publisher

product information

Product ID :

BML-SE544

Catalog Number :

BML-SE544-0050

Product Name :

LSD1 (human), (recombinant)

Product Type :

Protein

Size :

50 µg

list of Pubmed id :

25759518

Background :

The mono, di- and trimethylation of particular lysine residues in histone tails (e.g. histone H3 lysine-4 (H3K4), H3K9, H3K27, H3K36, H4K20) are implicated, along with a variety of other post-translational modifications (e.g. lysine acetylation) in the transmission of heritable epigenetic information and the control of chromatin structure and DNA transcription. LSD1 catalyzes the oxidative demethylation of mono- and dimethylated H3K4, producing hydrogen peroxide and formaldehyde in the process. H3K4 methylation is considered a transcription activating chromatin mark and in vivo LSD1 is frequently found in association with the transcriptional corepressor protein CoREST and HDACs 1 or 2. LSD1 is inhibited by a number of established monoamine oxidase inhibitor drugs. That and the fact that its expression is elevated in a number of cancers may make it a promising target for drug development.

ALTnames :

KDM1, Lysine-specific histone demethylase 1, BHC110, AOF2, KIAA0601

Purity :

≥90% (SDS-PAGE)

Buffer :

Liquid. In 8.1mM Na2HPO4, 1.5mM KH2PO4, pH 7.2, 138mM sodium chloride, 2.7mM KCl and 40% v/v glycerol.

Uses :

Useful tool to study LSD1 kinetics and inhibitor sensitivity and also the effect of the enzyme in transcriptional regulation, cell cycle progression, and oncogenesis.

Storage :

-80°C