Tyrosinase (human), (recombinant) (His-tag) | Enzo Life Sciences BML-SE535-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

Tyrosinase (human), (recombinant) (His-tag)

catalog :

BML-SE535-0100

quantity :

100 µg

product information

Product ID :

BML-SE535

Catalog Number :

BML-SE535-0100

Product Name :

Tyrosinase (human), (recombinant) (His-tag)

Product Type :

Protein

Size :

100 µg

Background :

Tyrosinase is a copper-containing enzyme that catalyzes four steps in the melanin and catecholamine synthesis pathways. Like tyrosine hydroxylase (EC 1.13.16.2), it can catalyze the formation of L-DOPA in the brain and nervous system. It oxidizes monophenols, but like catecholoxidase (EC 1.10.3.1), it can also oxidize o-diphenols to o-quinones. It is involved in cancer, Parkinson’s, pigmentation diseases, Alzheimer’s and obesity. Much of the research and inhibitor screening has used mushroom tyrosinase. However, mushroom tyrosinase interacts very differently with substrates and inhibitors compared to the human enzyme. In addition, commercially available mushroom tyrosinase is not always of good purity. Recombinant versions of human tyrosinase amino acids 1-345 or 1-378, also available commercially, are not functional due the lack of critical catalytic and structural residues.

ALTnames :

Monophenol monooxygenase

Purity :

≥85% (SDS-PAGE)

Buffer :

Liquid. In 50mM TRIS/HCl, pH 8.0, 1M NaCl, 0.05% Empigen BB, and 30% glycerol.

Uses :

Useful tool to study enzyme kinetics and screen for inhibitors.

Storage :

-80°C