This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
protein
product name :
ADAM17 (catalytic domain) (human), (recombinant) (His-tag)
catalog :
BML-SE268-0010
quantity :
10 µg
citations: 3
Reference
Rosner K, Guo Z, Orth P, Shipps G, Belanger D, Chan T, et al. The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors. Bioorg Med Chem Lett. 2010;20:1189-93 pubmed publisher
Zhang C, Lovering F, Behnke M, Zask A, Sandanayaka V, Sun L, et al. Synthesis and activity of quinolinylmethyl P1' alpha-sulfone piperidine hydroxamate inhibitors of TACE. Bioorg Med Chem Lett. 2009;19:3445-8 pubmed publisher
Patel I, Attur M, Patel R, Stuchin S, Abagyan R, Abramson S, et al. TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. J Immunol. 1998;160:4570-9 pubmed
product information
Product ID :
BML-SE268
Catalog Number :
BML-SE268-0010
Product Name :
ADAM17 (catalytic domain) (human), (recombinant) (His-tag)
Product Type :
Protein
Size :
10 µg
list of Pubmed id :
20022498, 19464885, 9574564
Background :
ADAM17/TACE is a soluble or membrane-bound metalloproteinase primarily responsible for activation of proTNF-α, while also targeting proteins such as fractalkine, amyloid precursor proteins, and CD40. ADAM17/TACE is involved in cancer, vascular disorders, and inflammatory diseases such as rheumatoid arthritis and focal ischemic injury. The catalytic domain of ADAM17/TACE is able to cleave proTNF-α and can be used in inhibitor screening.
ALTnames :
TACE, A disintegrin and metalloproteinase 17, Tumor necrosis factor-α-converting enzyme
Purity :
≥90% (SDS-PAGE)
Buffer :
Liquid. In 22.5mM TRIS, pH 7.5, containing 4.5µM ZnCl2, 0.0045% Brij-35 and 10% glycerol.
Uses :
Useful tool to study enzyme kinetics, cleave target substrates, screen inhibitors.
Storage :
-80°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.