Caspase-6 (human), (recombinant) | Enzo Life Sciences BML-SE170-5000 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

Caspase-6 (human), (recombinant)

catalog :

BML-SE170-5000

quantity :

5000 U

citations: 3

Reference
Gafni J, Papanikolaou T, DeGiacomo F, Holcomb J, Chen S, Menalled L, et al. Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment. J Neurosci. 2012;32:7454-65 pubmed publisher
Descamps O, Zhang Q, John V, Bredesen D. Induction of the C-terminal proteolytic cleavage of A?PP by statins. J Alzheimers Dis. 2011;25:51-7 pubmed publisher
Leyva M, DeGiacomo F, Kaltenbach L, Holcomb J, Zhang N, Gafni J, et al. Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chem Biol. 2010;17:1189-200 pubmed publisher

product information

Product ID :

BML-SE170

Catalog Number :

BML-SE170-5000

Product Name :

Caspase-6 (human), (recombinant)

Product Type :

Protein

Size :

5000 U

list of Pubmed id :

22649225, 21422530, 21095569

Background :

Effector caspase responsible for the cleavage of nuclear lamins in apoptosis. Caspase-6 cleavages of various other protein targets have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (b-amyloid precursor protein), Huntington’s disease (huntingtin).

ALTnames :

Mch2

Purity :

≥80% (SDS-PAGE)

Buffer :

Liquid. In 50mM HEPES, pH 7.4, containing 100mM sodium chloride, 0.5% CHAPS, 1mM EDTA, 10% glycerol and 10mM DTT.

Uses :

Useful tool to study enzyme regulation and kinetics, cleave target substrates, screen for inhibitors.

Storage :

-80°C