Reversine | Enzo Life Sciences BML-SC104-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Reversine

catalog :

BML-SC104-0005

quantity :

5 mg

citations: 4

Reference
Haschka M, Soratroi C, Kirschnek S, Hacker G, Hilbe R, Geley S, et al. The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest. Nat Commun. 2015;6:6891 pubmed publisher
D Alise A, Amabile G, Iovino M, Di Giorgio F, Bartiromo M, Sessa F, et al. Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol Cancer Ther. 2008;7:1140-9 pubmed publisher
Perreira M, Jiang J, Klutz A, Gao Z, Shainberg A, Lu C, et al. "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005;48:4910-8 pubmed
Chen S, Zhang Q, Wu X, Schultz P, Ding S. Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc. 2004;126:410-1 pubmed

product information

Product ID :

BML-SC104

Catalog Number :

BML-SC104-0005

Product Name :

Reversine

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

25922916, 18483302, 16033270, 14719906

Product Description :

Induces dedifferentiation in murine C2C12 myoblasts. The cells were also shown to regain multipluripotency following removal of the compound. Potent and selective A3 adenosine receptor antagonist (Ki = 0.66µM) and a novel aurora kinase inhibitor (IC50's of 30-550nM for blast colony formation assay).

ALTnames :

2-(4-Morpholinoanilino)-6-cyclohexylaminopurine

Purity :

≥98% (TLC)

Storage :

-20°C