p53 monoclonal antibody (PAb421) | Enzo Life Sciences BML-SA293-0050 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

p53 monoclonal antibody (PAb421)

catalog :

BML-SA293-0050

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PAb421

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

more info or order :

Enzo Life Sciences product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; mouse; fig 4	Duplan E, Giordano C, Checler F, Alves da Costa C. Direct Î±-synuclein promoter transactivation by the tumor suppressor p53. Mol Neurodegener. 2016;11:13 pubmed publisher
	Xiao J, Lin H, Luo X, Luo X, Wang Z. miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress. EMBO J. 2011;30:5021 pubmed publisher
	Kawada J, Wada H, Isobe M, Gnjatic S, Nishikawa H, Jungbluth A, et al. Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination. Int J Cancer. 2012;130:584-92 pubmed publisher
	Kirschner R, Sänger K, Müller G, Engeland K. Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site. Nucleic Acids Res. 2008;36:2969-80 pubmed publisher

product information

Product ID :

BML-SA293

Catalog Number :

BML-SA293-0050

Product Name :

p53 monoclonal antibody (PAb421)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

50 µg

list of Pubmed id :

22166998, 21413013, 18388131

Clone :

PAb421

Isotype :

IgG2a

Product Description :

PAb421 antibody induces allosteric changes in certain tumor-derived p53 mutants and restores tumor suppressor activity. Microinjection of PAb421 into SW480 colorectal carcinoma cells restored transcriptional activation function to the resident mutant p53 (Arg to His 273, Pro to Ser 309). The epitope for PAb421 is contained within the "p53 activator peptide" 46. Thus the antibody recognizes this peptide and has been used to examine cellular uptake of the p53 activator peptide.

SPECIES REACTIVITY :

Human, Mouse, Rat

ALTnames :

TRP53, Tumor protein p53

Immunogen :

Synthetic peptide corresponding to aa 371-380 of human p53.

Buffer :

Liquid. In phosphate buffer containing 0.02% sodium azide.

Application Summary :

ICC, IHC, IP, WB

Storage :

+4°C

more info or order :

Enzo Life Sciences product webpage