Ub+1 polyclonal antibody | Enzo Life Sciences BML-PW9780-0025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Ub+1 polyclonal antibody

catalog :

BML-PW9780-0025

quantity :

25 µl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

product information

Product ID :

BML-PW9780

Catalog Number :

BML-PW9780-0025

Product Name :

Ub+1 polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

25 µl

SPECIES REACTIVITY :

Human

Background :

Ub+1 is a novel form of ubiquitin that has been selectively observed in the brains of Alzheimer's patients, including those with nonfamilial Alzheimer's disease. Ub+1 is an efficient substrate for polyubiquitinylation in vitro and in transfected human cells. The resulting polyubiquitin chains are refractory to disassembly by deubiquitinating enzymes and potently inhibit the degradation of a polyubiquitinylated substrate by purified 26S proteasomes. Thus, expression of Ub+1 in aging brain could result in dominant inhibition of the Ub-proteasome system, leading to neuropathologic consequences. Expression of Ub+1 occurs through a phenomenon known as molecular misreading, in which non-DNA-encoded dinucleotide deletion(s) are found in mRNA within or adjacent to GAGAG motifs. A mechanism by which Ub+1 expression could lead to dominant inhibition of the Ub-proteasome system has been demonstrated.

ALTnames :

Ubiquitin+1

Immunogen :

Synthetic peptide corresponding to aa 76-95 of human Ub+1.

Buffer :

Liquid. Antiserum containing 0.1% sodium azide.

Application Summary :

IHC, WB

Storage :

-20°C