This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
SUMO-2/3 (human) (NT) polyclonal antibody
catalog :
BML-PW9465-0025
quantity :
25 µl
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
product information
Product ID :
BML-PW9465
Catalog Number :
BML-PW9465-0025
Product Name :
SUMO-2/3 (human) (NT) polyclonal antibody
Host species :
Rabbit
Clonality :
Polyclonal
Product Type :
Antibody
Size :
25 µl
list of Pubmed id :
25764370
SPECIES REACTIVITY :
Human
Background :
The small ubiquitin-related modifier SUMO belongs to the growing family of ubiquitin-related proteins involved in post-translational protein modification. It is present in all eukaryotic kingdoms and is highly conserved from yeast to humans. Two ubiquitin like proteins, SUMO-2 and SUMO-3 have been identified that are related to SUMO-1 but which are functionally distinct. Whereas invertebrates have only one SUMO gene, three members of the SUMO family have been described in vertebrates, SUMO-1 and the close homologues SUMO-2 and SUMO-3 with some 50% homology between SUMO-1 and SUMO-2/3, and 86% identity between SUMO-2 and SUMO-3. The SUMO family members have a short N-terminal extension that is absent in ubiquitin, and the function of which is unknown and the sequence of which varies between the three family members. In vivo studies have indicated that PML is modified by SUMO-1 and SUMO-2/3, although the functional significance of SUMO-2/3 conjugation has not been revealed. Functional SUMO modification sites present in the N-terminal regions of SUMO-2 and SUMO-3 are utilised by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO-2 and SUMO-3 on protein substrates in vitro and SUMO-2 chains have been detected in vivo. The ability to form polymeric chains is not shared by SUMO-1. Thus, although all SUMO species share the same conjugation machinery, modification by SUMO-1 and SUMO2/3 has distinct functional consequences  which are only now beginning to be defined more clearly.
ALTnames :
Small ubiquitin-related modifier 2/3
Immunogen :
Synthetic peptide corresponding to aa 1-15 of human SUMO-2.
Buffer :
Liquid. In PBS containing 0.01% sodium azide.
Application Summary :
WB
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.