Parkin (human) polyclonal antibody | Enzo Life Sciences BML-PW9365-0025 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Parkin (human) polyclonal antibody

catalog :

BML-PW9365-0025

quantity :

25 µl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation

product information

Product ID :

BML-PW9365

Catalog Number :

BML-PW9365-0025

Product Name :

Parkin (human) polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

25 µl

SPECIES REACTIVITY :

Human

Background :

Parkin is a ubiquitin-protein ligase (E3), and mutations in the Parkin gene appear to be closely associated with autosomal recessive juvenile Parkinson’s disease. Parkin has been localised to Lewy bodies in patients with sporadic Parkinson’s disease, and in peri-nuclear aggresome-like inclusions in cells over-expressing wild-type Parkin where proteasomal activity has also been inhibited4. Both types of inclusion also contain ubiquitin, α-synuclein, proteasomal subunits and heat shock proteins. A recent paper suggests that loss of proteasomal activity leads to Parkin accumulation with a concomitant reduction in E3 ligase activity resulting in Lewy body formation5.Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy (mitophagy).

Immunogen :

Synthetic peptide corresponding to aa 399-415 (CE339QARWEAASKETIK412) of human parkin. A single amino acid substitution (A405E) exists in both the rat and mouse homologues.

Buffer :

Liquid. In PBS.

Application Summary :

IHC, IP, WB

Storage :

-20°C