COP9 signalosome Csn1 subunit polyclonal antibody | Enzo Life Sciences BML-PW8285-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

COP9 signalosome Csn1 subunit polyclonal antibody

catalog :

BML-PW8285-0100

quantity :

100 µl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

application :

western blot, immunohistochemistry, immunoprecipitation

product information

Product ID :

BML-PW8285

Catalog Number :

BML-PW8285-0100

Product Name :

COP9 signalosome Csn1 subunit polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

100 µl

list of Pubmed id :

19826004, 10203806, 9723217, 9707402

SPECIES REACTIVITY :

Human, Mouse, Porcine, Frog

Background :

The COP9 signalosome, once defined as a repressor complex of light activated development in Arabidopsis, has recently been found in humans and is probably present in most multicellular organisms. The COP9 signalosome is closely related to the lid sub-complex of the 26S proteasome in structural composition and probably shares a common evolutionary ancestor. A multifaceted role of the COP9 signalosome in cell-signalling processes is hinted at by its associated novel kinase activity, as well as the involvement of its subunits in regulating multiple cell-signalling pathways and cell-cycle progression. The molecular genetic studies in Arabidopsis suggest that the complex functions as part of a highly conserved regulatory network, whose physiological role in animals has yet to be determined. The COP9 signalosome, also known as the the COP9 complex and JAB1-containing signalosome, is a conserved nuclear protein complex found in plants and animals. It is composed of eight distinct subunits, designated S1 to S8 (very recently re-designated Csn1-Csn82) according to the molecular weight of the mammalian complex subunits. Subunit composition and the subunit sequences are substantially conserved between the mammalian and the plant complexes, implying that the complex has a conserved cellular function in higher eukaryotic organisms. Subunit 1 (Csn1) was previously identified as GPS1, which was isolated by its ability to rescue the lethality of a S. cerevisiae mutant deleted for the α-subunit of trimeric G protein. Transient expression of full length GPS1 in mammalian cells was shown to inhibit JNK1 and to repress JUN-dependent promoter activity. Csn1 shows homology to 19S proteasome regulatory subunit Rpn7 (S10a).

Immunogen :

Recombinant human COP9 signalosome (Csn1 subunit) (aa 230-500).

Buffer :

Liquid. In PBS containing 50% glycerol and 10mM sodium azide.

Application Summary :

IHC, IP, WB

Storage :

-20°C