This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Proteasome 20S β5t subunit (human) monoclonal antibody (b8-17)
catalog :
BML-PW1020-0025
quantity :
25 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
b8-17
reactivity :
human, mouse
application :
western blot
product information
Product ID :
BML-PW1020
Catalog Number :
BML-PW1020-0025
Product Name :
Proteasome 20S β5t subunit (human) monoclonal antibody (b8-17)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
25 µl
Clone :
b8-17
Isotype :
IgG1
SPECIES REACTIVITY :
Human, Mouse
Background :
When cells are stimulated with pro-inflammatory cytokines, most of their constitutively expressed proteasomes are replaced with immunoproteasomes, which increase the production of peptides for presentation on MHC class I molecules. In addition, cortical thymic epithelial cells selectively express a type of proteasome known as the thymoproteasome, in which the β5i immunoproteasome subunit has been replaced by the thymus specific proteasome subunit β5t. The thymoproteasome is required for the positive selection of thymocytes and shaping the T cell receptor repertoire of cytotoxic T lymphocytes. In addition mice deficient in β5t display defective development of CD8(+) T cells in the thymus suggesting a key role for β5t and the thymoproteasome in generating MHC class I-restricted CD8(+) T cells.
ALTnames :
Proteasome subunit β type-11
Immunogen :
Recombinant human 20S proteasome β5t subunit.
Specificity :
Recognizes the β5t subunit of the 20S proteasome.
Buffer :
Liquid. In PBS containing 0.01% sodium azide.
Application Summary :
WB
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.