This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
USP18 (human) polyclonal antibody
catalog :
BML-PW0945-0100
quantity :
100 µl
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
product information
Product ID :
BML-PW0945
Catalog Number :
BML-PW0945-0100
Product Name :
USP18 (human) polyclonal antibody
Host species :
Rabbit
Clonality :
Polyclonal
Product Type :
Antibody
Size :
100 µl
SPECIES REACTIVITY :
Human
Background :
USP18 (UBP43) is a specific deconjugating enzyme for ISG15, a vertebrate ubiquitin like protein strongly upregulated by type I interferon following bacterial or viral infection. Whilst the molecular and regulatory consequences of ISGylation are not fully understood, the absence of USP18 has a profound effect on innate immunity, leading to increased resistance to certain viral infections. Notably, these effects do not appear to be contingent upon the proteolytic activity of USP18 suggesting additional roles for USP18 over and above that of an ISG15 specific protease. USP18 has been shown to significantly limit operation of the extrinsic apoptotic pathway triggered by type I interferon and drugs.
ALTnames :
UBP43, ISG15 specific protease
Immunogen :
Synthetic peptide corresponding to aa 89-100 of human USP18.
Buffer :
Liquid. In PBS containing 0.01% sodium azide. For further dilutions use PBS pH 7.4 and 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used).
Application Summary :
WB
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.