FAT10 (human) monoclonal antibody (4F1) | Enzo Life Sciences BML-PW0765-0025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

FAT10 (human) monoclonal antibody (4F1)

catalog :

BML-PW0765-0025

quantity :

25 µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4F1

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

product information

Product ID :

BML-PW0765

Catalog Number :

BML-PW0765-0025

Product Name :

FAT10 (human) monoclonal antibody (4F1)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

25 µl

Clone :

4F1

Isotype :

IgG2a

SPECIES REACTIVITY :

Human

Background :

FAT10 is a ubiquitin-like protein (UBL), that is encoded in the major histocompatibility complex class I locus and is synergistically inducible with IFN-α and TNF-α. It is composed of two ubiquitin-like domains and possesses a free C-terminal diglycine motif that is required for FAT10 conjugate formation. Conjugation with FAT10 provides an alternative, cytokine inducible, ubiquitin-independent targeting mechanism for protein degradation by the proteasome, mediated by factors such as NUB1L. Although its function has not been fully elucidated, FAT10 has been shown to play important roles in various cellular processes including cell cycle control, chromosomal stability and apoptosis, and its up-regulation has been observed in various forms of cancer and HIV-associated renal disease. FAT10 expression is negatively regulated by the p53 tumour suppressor protein.

ALTnames :

Ubiquitin D

Immunogen :

Recombinant human FAT10.

Buffer :

Liquid. In PBS containing 0.01% sodium azide.

Application Summary :

ICC, IP, WB

Storage :

-20°C