This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Polyubiquitin (K63-linkage-specific) monoclonal antibody (HWA4C4) (HRP conjugate)
catalog :
BML-PW0605-0025
quantity :
25 µg
clonality :
monoclonal
host :
mouse
conjugate :
HRP
clone name :
HWA4C4

The same clone is also sold as:
reactivity :
human, mouse, rat, dogs
application :
western blot
citations: 5
Reference
Su X, Yan H, Huang Y, Yun H, Zeng B, Wang E, et al. Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus. Sci Rep. 2015;5:18588 pubmed publisher
Zhang P, Fu W, Fu A, Ip N. S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength. Nat Commun. 2015;6:8665 pubmed publisher
Lim G, Chua D, Basil A, Chan H, Chai C, Arumugam T, et al. Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy. J Biol Chem. 2015;290:16882-93 pubmed publisher
Zhou F, Zhang X, van Dam H, Ten Dijke P, Huang H, Zhang L. Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation. J Biol Chem. 2012;287:11002-10 pubmed publisher
Paine S, Bedford L, Thorpe J, Mayer R, Cavey J, Bajaj N, et al. Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration. Neurosci Lett. 2009;460:205-8 pubmed publisher
product information
Product ID :
BML-PW0605
Catalog Number :
BML-PW0605-0025
Product Name :
Polyubiquitin (K63-linkage-specific) monoclonal antibody (HWA4C4) (HRP conjugate)
Host species :
Mouse
Clonality :
Monoclonal
Conjugation :
HRP
Product Type :
Antibody
Size :
25 µg
list of Pubmed id :
26503494
Clone :
HWA4C4
Isotype :
IgG2a
SPECIES REACTIVITY :
Species independent
Background :
Modification of proteins by addition of K63-linked polyubiquitin chains is implicated in a variety of cellular events, including DNA repair, signal transduction and receptor endocytosis.
Immunogen :
Synthetic peptide containing the ubiquitin K63-isopeptide motif.
Specificity :
Recognizes K63-linked polyubiquitin in wide range of species.
Buffer :
Liquid. In 1X PBS, pH 7.2.
Uses :
K63-linked polyubiquitin modified proteins comprise only a proportion of total cellular polyubiquitinylated species. Increased sample loading may therefore be required for analysis by Western blotting compared to equivalent experiments using general ubiquitin antibodies, despite the enhanced detection capability of the HWA4C4 HRP conjugated antibody.
Application Summary :
WB
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.