Lactacystin | Enzo Life Sciences BML-PI104-0200 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Lactacystin

catalog :

BML-PI104-0200

quantity :

200 µg

citations: 12

Reference
Schmidt N, Domingues P, Golebiowski F, Patzina C, Tatham M, Hay R, et al. An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity. Proc Natl Acad Sci U S A. 2019;116:17399-17408 pubmed publisher
Pienaar I, Gartside S, Sharma P, de Paola V, Gretenkord S, Withers D, et al. Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease. Mol Neurodegener. 2015;10:47 pubmed publisher
Lindholm P, Sivapurapu N, Jovanovic B, Kajdacsy Balla A. Monocyte-Induced Prostate Cancer Cell Invasion is Mediated by Chemokine ligand 2 and Nuclear Factor-ÎºB Activity. J Clin Cell Immunol. 2015;6: pubmed
Husmann K, Ducommun P, Sabile A, Pedersen E, Born W, Fuchs B. Signal transduction and downregulation of C-MET in HGF stimulated low and highly metastatic human osteosarcoma cells. Biochem Biophys Res Commun. 2015;464:1222-1227 pubmed publisher
Harrison I, Crum W, Vernon A, Dexter D. Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors. Br J Pharmacol. 2015;172:4200-15 pubmed publisher
RodrÃguez GarcÃa A, Svensson E, Gil Hoyos R, Fajardo C, Rojas L, Arias Badia M, et al. Insertion of exogenous epitopes in the E3-19K of oncolytic adenoviruses to enhance TAP-independent presentation and immunogenicity. Gene Ther. 2015;22:596-601 pubmed publisher
Kirk C, Powell S, Miller E. Assessment of cytokine-modulated proteasome activity. Methods Mol Biol. 2014;1172:147-62 pubmed publisher
Ball D, Tay H, Bell K, Coates M, Al Riyami L, Rzepecka J, et al. Mast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62. J Parasitol Res. 2013;2013:961268 pubmed publisher
Hernebring M, Fredriksson A, Liljevald M, Cvijovic M, Norrman K, Wiseman J, et al. Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28. Sci Rep. 2013;3:1381 pubmed publisher
Dasgupta A, Zheng J, Bizzozero O. Protein carbonylation and aggregation precede neuronal apoptosis induced by partial glutathione depletion. ASN Neuro. 2012;4: pubmed publisher
Leskelä T, Lackman J, Vierimaa M, Kobayashi H, Bouvier M, Petäjä Repo U. Cys-27 variant of human ?-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. J Biol Chem. 2012;287:5008-20 pubmed publisher
Patterson S, Reithmeier R. Cell surface rescue of kidney anion exchanger 1 mutants by disruption of chaperone interactions. J Biol Chem. 2010;285:33423-34 pubmed publisher

product information

Product ID :

BML-PI104

Catalog Number :

BML-PI104-0200

Product Name :

Lactacystin

Product Type :

Biochemical

Size :

200 µg

list of Pubmed id :

26394842, 26317041, 26210452, 26040297, 25994521, 24908302, 23476740, 23459332, 22376187, 22184124

Product Description :

A potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic β-subunit. Has no effect on serine or cysteine proteases. Induces apoptosis inhuman monoblast U937 cells. Inhibits NF-κB activation by inhibiting IκB degradation (IC50=10 µM). Inhibits the ubiquitin proteasome pathway in cell culture. Inhibits cathepsin A. Upregulates HSP70 and HSP22, suggesting an initial neuroprotective pathway. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells.

Purity :

≥97% (HPLC)

Storage :

-20°C