MG-132 | Enzo Life Sciences BML-PI102-0025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

MG-132

catalog :

BML-PI102-0025

quantity :

25 mg

citations: 13

Reference
Nakagawa K, Kohara T, Uehata Y, Miyakawa Y, Sato Ueshima M, Okubo N, et al. PIAS3 enhances the transcriptional activity of HIF-1Î± by increasing its protein stability. Biochem Biophys Res Commun. 2016;469:470-6 pubmed publisher
Filardy A, He J, Bennink J, Yewdell J, Kelsall B. Posttranscriptional control of NLRP3 inflammasome activation in colonic macrophages. Mucosal Immunol. 2016;9:850-8 pubmed publisher
Bae W, Choi J, Kim J, Jeong J. Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor-1Î± expression during tumor progression. Biochem Pharmacol. 2015;98:41-50 pubmed publisher
Teng Y, Rezvani K, De Biasi M. UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. Biochem Pharmacol. 2015;97:518-530 pubmed publisher
Li J, Ma W, Li H, Hou N, Wang X, Kim I, et al. NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins. J Biol Chem. 2015;290:23850-62 pubmed publisher
Cui D, Arima M, Takubo K, Kimura T, Horiuchi K, Minagawa T, et al. ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function. Sci Rep. 2015;5:12796 pubmed publisher
Husmann K, Ducommun P, Sabile A, Pedersen E, Born W, Fuchs B. Signal transduction and downregulation of C-MET in HGF stimulated low and highly metastatic human osteosarcoma cells. Biochem Biophys Res Commun. 2015;464:1222-1227 pubmed publisher
Kim C, Yun N, Lee J, Youdim M, Ju C, Kim W, et al. Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death. Cell Death Differ. 2016;23:333-46 pubmed publisher
Hwang J, Kim H, Kang B, Kim D, Ryoo Z, Choi S, et al. RGS19 converts iron deprivation stress into a growth-inhibitory signal. Biochem Biophys Res Commun. 2015;464:168-75 pubmed publisher
Lindert U, Weis M, Rai J, Seeliger F, Hausser I, Leeb T, et al. Molecular Consequences of the SERPINH1/HSP47 Mutation in the Dachshund Natural Model of Osteogenesis Imperfecta. J Biol Chem. 2015;290:17679-89 pubmed publisher
Hofmeister Brix A, Lenzen S, Baltrusch S. The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells. Biochem J. 2013;456:173-84 pubmed publisher
Shen D, Coleman J, Chan E, Nicholson T, Dai L, Sheppard P, et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011;60:173-85 pubmed publisher
Salway K, Page M, Faure P, Burness G, Stuart J. Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species. Age (Dordr). 2011;33:33-47 pubmed publisher

product information

Product ID :

BML-PI102

Catalog Number :

BML-PI102-0025

Product Name :

MG-132

Product Type :

Peptide

Size :

25 mg

list of Pubmed id :

26697750, 26627461, 26297910, 26265139, 26260793, 26242473, 26210452, 26206088, 26116529, 26004778

Product Description :

MG-132 is a potent, cell permeable and selective proteasome inhibitor (Ki = 4nM).1 It inhibits NF-κB activation by preventing IκB degradation (IC50 = 3μM). The peptide blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1μM MG-132, 2 h.). It also stimulates neurite outgrowth in PC12 cells (20nM optimal). The peptide has also been reported to increase the survival rate of mesenchymal stem cells following their transplantation. IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0.85 and 0.1μM respectively. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-132 activates autophagy.

ALTnames :

Z-LLL-CHO

Purity :

≥98%

Storage :

-80°C