Calpeptin | Enzo Life Sciences BML-PI101-0050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Calpeptin

catalog :

BML-PI101-0050

quantity :

50 mg

citations: 10

Reference
Fujii T, Ishikawa M, Kubo A, Tanaka Y. Effect of SI-591, a new class of cathepsin K inhibitor with peptidomimetic structure, on bone metabolism in vitro and in vivo. Bone. 2015;81:427-34 pubmed publisher
Kondo M, Yamato M, Takagi R, Namiki H, Okano T. Membrane-Permeable Calpain Inhibitors Promote Rat Oral Mucosal Epithelial Cell Proliferation by Inhibiting IL-1Î± Signaling. PLoS ONE. 2015;10:e0134240 pubmed publisher
Feng W, Guo J, Huang H, Xia B, Liu H, Li J, et al. Human normal bronchial epithelial cells: a novel in vitro cell model for toxicity evaluation. PLoS ONE. 2015;10:e0123520 pubmed publisher
Catalano J, Deaton D, Furfine E, Hassell A, McFadyen R, Miller A, et al. Exploration of the P1 SAR of aldehyde cathepsin K inhibitors. Bioorg Med Chem Lett. 2004;14:275-8 pubmed
Griscavage J, Wilk S, Ignarro L. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B. Proc Natl Acad Sci U S A. 1996;93:3308-12 pubmed
Saito K, Nixon R. Specificity of calcium-activated neutral proteinase (CANP) inhibitors for human mu CANP and mCANP. Neurochem Res. 1993;18:231-3 pubmed
Figueiredo Pereira M, Banik N, Wilk S. Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain. J Neurochem. 1994;62:1989-94 pubmed
Pinter M, Aszodi A, Friedrich P, Ginzburg I. Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells. Neurosci Lett. 1994;170:91-3 pubmed
Ebisui C, Tsujinaka T, Kido Y, Iijima S, Yano M, Shibata H, et al. Role of intracellular proteases in differentiation of L6 myoblast cells. Biochem Mol Biol Int. 1994;32:515-21 pubmed
Banno Y, Nakashima S, Hachiya T, Nozawa Y. Endogenous cleavage of phospholipase C-beta 3 by agonist-induced activation of calpain in human platelets. J Biol Chem. 1995;270:4318-24 pubmed

product information

Product ID :

BML-PI101

Catalog Number :

BML-PI101-0050

Product Name :

Calpeptin

Product Type :

Biochemical

Size :

50 mg

list of Pubmed id :

26297834, 26230502, 25861018, 14684342, 8622934, 8474564, 8158145, 8041520, 8032318, 7876193

Product Description :

Membrane permeable inhibitor of calpain I and II, cathepsin L and cathepsin K (IC50=0.11 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin (Prod. No. ALX-450-006) or thrombin. Inhibits LPS induced iNOS transcription and NF-κB activation, possibly via proteasome inhibition.

ALTnames :

Z-Leu-norleucinal, N-Benzyloxycarbonyl-L-leucyl-norleucinal

Purity :

≥98% (HPLC)

Storage :

-20°C