Rolipram | Enzo Life Sciences BML-PD175-0050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Rolipram

catalog :

BML-PD175-0050

quantity :

50 mg

citations: 6

Reference
Wang Z, Zhang L, Liang Y, Zhang C, Xu Z, Zhang L, et al. Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin. Sci Rep. 2015;5:12012 pubmed publisher
Mullershausen F, Zécri F, Cetin C, Billich A, Guerini D, Seuwen K. Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat Chem Biol. 2009;5:428-34 pubmed publisher
Underwood D, Kotzer C, Bochnowicz S, Osborn R, Luttmann M, Hay D, et al. Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. J Pharmacol Exp Ther. 1994;270:250-9 pubmed
Reeves M, Leigh B, England P. The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors. Biochem J. 1987;241:535-41 pubmed
Schneider H, Schmiechen R, Brezinski M, Seidler J. Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur J Pharmacol. 1986;127:105-15 pubmed
Moore J, Combs D, Tobia A. Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue. Biochem Pharmacol. 1991;42:679-83 pubmed

product information

Product ID :

BML-PD175

Catalog Number :

BML-PD175-0050

Product Name :

Rolipram

Product Type :

Biochemical

Size :

50 mg

list of Pubmed id :

26153625, 19430484, 8035322, 3036066, 3019721, 1650219

Product Description :

Selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC50=1 µM). A rolipram insensitive PDE IV subtype has been described.

ALTnames :

(±)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

Purity :

≥98% (TLC)

Storage :

Ambient