This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Clozapine N-oxide
catalog :
BML-NS105-0005
quantity :
5 mg
citations: 17
Reference
Zhu M, Kasaragod D, Kikutani K, Taguchi K, Aizawa H. A Novel Microcontroller-Based System for the Wheel-Running Activity in Mice. Eneuro. 2021;8: pubmed publisher
Zheng X, Salinas K, Velez D, Nakayama T, Lin X, Banerjee D, et al. Host interneurons mediate plasticity reactivated by embryonic inhibitory cell transplantation in mouse visual cortex. Nat Commun. 2021;12:862 pubmed publisher
Huang T, Hsu T, Lin M, Chuang H, Hu H, Sun C, et al. Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory. Cell Rep. 2019;29:34-48.e4 pubmed publisher
Wang Y, Kim J, Schmit M, Cho T, Fang C, Cai H. A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding. Nat Commun. 2019;10:2769 pubmed publisher
Jackson J, Karnani M, Zemelman B, Burdakov D, Lee A. Inhibitory Control of Prefrontal Cortex by the Claustrum. Neuron. 2018;99:1029-1039.e4 pubmed publisher
Zelikowsky M, Hui M, Karigo T, Choe A, Yang B, Blanco M, et al. The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress. Cell. 2018;173:1265-1279.e19 pubmed publisher
Bellini S, Fleming K, De M, McCauley J, Petroccione M, D Brant L, et al. Neuronal Glutamate Transporters Control Dopaminergic Signaling and Compulsive Behaviors. J Neurosci. 2018;38:937-961 pubmed publisher
Pienaar I, Gartside S, Sharma P, de Paola V, Gretenkord S, Withers D, et al. Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease. Mol Neurodegener. 2015;10:47 pubmed publisher
Yi F, DeCan E, Stoll K, Marceau E, Deisseroth K, Lawrence J. Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures. Epilepsia. 2015;56:297-309 pubmed publisher
Sano Y, Shobe J, Zhou M, Huang S, Shuman T, Cai D, et al. CREB regulates memory allocation in the insular cortex. Curr Biol. 2014;24:2833-7 pubmed publisher
Robinson S, Todd T, Pasternak A, Luikart B, Skelton P, Urban D, et al. Chemogenetic silencing of neurons in retrosplenial cortex disrupts sensory preconditioning. J Neurosci. 2014;34:10982-8 pubmed publisher
Lesch A, Rubil S, Thiel G. Activation and inhibition of transient receptor potential TRPM3-induced gene transcription. Br J Pharmacol. 2014;171:2645-58 pubmed
Yi F, Ball J, Stoll K, Satpute V, Mitchell S, Pauli J, et al. Direct excitation of parvalbumin-positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition. J Physiol. 2014;592:3463-94 pubmed publisher
Zhong P, Liu X, Zhang Z, Hu Y, Liu S, Lezama Ruiz M, et al. Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors. J Neurosci. 2014;34:6352-66 pubmed publisher
Kaufmann A, Keim A, Thiel G. Regulation of immediate-early gene transcription following activation of G?(q)-coupled designer receptors. J Cell Biochem. 2013;114:681-96 pubmed publisher
Midkiff J, Borochoff Porte N, White D, Johnson D. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS ONE. 2011;6:e25395 pubmed publisher
Alvarez Curto E, Prihandoko R, Tautermann C, Zwier J, Pediani J, Lohse M, et al. Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Mol Pharmacol. 2011;80:1033-46 pubmed publisher
product information
Product ID :
BML-NS105
Catalog Number :
BML-NS105-0005
Product Name :
Clozapine N-oxide
Product Type :
Biochemical
Size :
5 mg
list of Pubmed id :
26394842, 25495999, 25454591, 25122898, 24895737, 24879872, 24790206, 23059951, 21966518, 21880827
Product Description :
Major metabolite of clozapine. Possesses little or no activity at 5-HT receptors.
Background :
Clozapine is an antipsychotic medication used in the treatment of schizophrenia, and is also sometimes used off-label for the treatment of bipolar disorder and borderline personality disorder. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Purity :
≥99% (HPLC)
Buffer :
Contains 1 equivalent of methanol.
Storage :
Ambient
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.