Tubacin | Enzo Life Sciences BML-GR362-0500 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Tubacin

catalog :

BML-GR362-0500

quantity :

500 µg

citations: 8

Reference
Namdar M, Perez G, Ngo L, Marks P. Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. Proc Natl Acad Sci U S A. 2010;107:20003-8 pubmed publisher
Butler K, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski A. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc. 2010;132:10842-6 pubmed publisher
Kawada J, Zou P, Mazitschek R, Bradner J, Cohen J. Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis. J Biol Chem. 2009;284:17102-9 pubmed publisher
Ding H, Dolan P, Johnson G. Histone deacetylase 6 interacts with the microtubule-associated protein tau. J Neurochem. 2008;106:2119-30 pubmed publisher
Haggarty S, Koeller K, Wong J, Butcher R, Schreiber S. Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chem Biol. 2003;10:383-96 pubmed
Wong J, Hong R, Schreiber S. Structural biasing elements for in-cell histone deacetylase paralog selectivity. J Am Chem Soc. 2003;125:5586-7 pubmed
Haggarty S, Koeller K, Wong J, Grozinger C, Schreiber S. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A. 2003;100:4389-94 pubmed
Sternson S, Wong J, Grozinger C, Schreiber S. Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin. Org Lett. 2001;3:4239-42 pubmed

product information

Product ID :

BML-GR362

Catalog Number :

BML-GR362-0500

Product Name :

Tubacin

Product Type :

Biochemical

Size :

500 µg

list of Pubmed id :

21037108, 20614936, 19386607, 18636984, 12770821, 12733869, 12677000, 11784187

Product Description :

Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable inhibitor of HDAC6 (IC50=0.004µM). IC50's for the other HDACs are 1000-fold higher, making tubacin both more selective and more potent than Tubastatin A, which also inhibits HDAC8. Concentration in cell culture experiments typically ranges from 2-50µM.

ALTnames :

N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-1,3-oxazol-2-yl)sulfanyl]methyl}-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl}phenyl)-N'-hydroxyoctanediamide

Purity :

≥96% (ELSD)

Storage :

-80°C