Scriptaid | Enzo Life Sciences BML-GR326-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Scriptaid

catalog :

BML-GR326-0005

quantity :

5 mg

citations: 4

Reference
Huber K, Doyon G, Plaks J, Fyne E, Mellors J, Sluis Cremer N. Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells. J Biol Chem. 2011;286:22211-8 pubmed publisher
Keen J, Yan L, Mack K, Pettit C, Smith D, Sharma D, et al. A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine. Breast Cancer Res Treat. 2003;81:177-86 pubmed
Hu E, Dul E, Sung C, Chen Z, Kirkpatrick R, Zhang G, et al. Identification of novel isoform-selective inhibitors within class I histone deacetylases. J Pharmacol Exp Ther. 2003;307:720-8 pubmed
Su G, Sohn T, Ryu B, Kern S. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Res. 2000;60:3137-42 pubmed

product information

Product ID :

BML-GR326

Catalog Number :

BML-GR326-0005

Product Name :

Scriptaid

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

21531716, 14620913, 12975486, 10866300

Product Description :

Inhibitor of histone deacetylase (HDAC) (HDAC1 and 3: IC50~0.6µM; HDAC8: IC50~1µM) with lower toxicity than trichostatin A (Prod. No. BML-GR309). Inhibits tumor growth in vitro and in vivo and, in conjunction with 5-aza-2’-deoxycytidine (Prod. No. ALX-480-096), enhances expression of estrogen receptor α. Optimal concentration 2-2.5μg/ml (6-8μM). A negative control is available (Prod. No. BML-GR327).

ALTnames :

6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide

Purity :

≥97% (TLC)

Storage :

-20°C